Results 141 to 150 of about 19,728,514 (315)

Signaling System Renovation Key Technology Solutions of Suzhou Rail Transit Line 11 and Line 3 for Through Train Operation

Chengshi guidao jiaotong yanjiu
［Objective］To enable the through train operation between Suzhou Rail Transit Line 11 and Line 3, a customized signaling system upgrade solution is required based on the unique characteristics and operational demands of the lines, aiming to achieve the ...
LIU Dongdong, ZHOU Yi, SHI Yufeng, TANG Tao   +3 more
doaj   +1 more source

Cross-regulation in a three-component cell envelope stress signaling system of <i>Brucella</i>. [PDF]

mBio, 2023
Chen X, Alakavuklar MA, Fiebig A, Crosson S.   +3 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Spatiotemporal regulation of the BarA/UvrY two-component signaling system. [PDF]

J Biol Chem, 2023
Contreras FU, Camacho MI, Pannuri A, Romeo T, Alvarez AF, Georgellis D.   +5 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

WNT Signaling in Disease

, 2019
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development.
Isabelle Sung, Li Ng, Qian Tan, Jahnavi Suresh, Jan Gruber, Prameet Kaur, Nawat Bunnag, Nicholas Tolwinski   +7 more
core   +1 more source

Optimization of Urban Rail Transit Signaling System Functions Based on Alternate Day Depot Return Operation Mode

Chengshi guidao jiaotong yanjiu
Objective In the alternate day depot return operation mode, trains either stay overnight on the mainline or run continuously day and night. The relevant functions of existing urban rail transit signaling system can no longer meet the requirements ...
CHAI Juan
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Operation Control Method for Degraded Trains after Shanghai Rail Transit Lines 3 and 4 Signaling System Upgrade and Renovation

Chengshi guidao jiaotong yanjiu
Objective After the upgrade of Shanghai Rail Transit Lines 3 and 4 signaling systems, their functions are highly concentrated in the on-board train controller.
LI Yongzheng
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source