Results 121 to 130 of about 31,177,116 (343)

Implications of Notch Signaling in Taste Cell Replacement [PDF]

, 2017
Cyclophosphamide (CYP) was one of the first chemotherapy drugs developed and used to treat several types of cancer, by disrupting proliferative cells. Unfortunately, CYP is unable to differentiate between cancerous cells and healthy cells turning over ...
D\u27Alessandro, Nicholas B
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Status and Development of Train Tracking Technology for CBTC Signaling System

Kongzhi Yu Xinxi Jishu, 2019
The existing train tracking technology research of communication based train control (CBTC) signaling system is generally limited to details or particular characteristics.
WANG Lili, LI Lei
doaj  

Analysis and Solution Schemes for Interference on Metro Signaling System Axle Counting Equipment

Chengshi guidao jiaotong yanjiu
[Objective] During the system commissioning, train debugging and trial operation on Chengdu Metro Line 18, the axle counting equipment exhibits AIO (abnormal interference and occupation) due to various disturbances in different scenarios, significantly ...
Rongbing YANG, Jianbin LIANG, Guanhua TAN, Zheng WANG   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Time Synchronization Scheme for Train FAO Signaling System

Chengshi guidao jiaotong yanjiu
[Objective] Time synchronization is the foundation for ensuring the coordinated linkage of sub-systems within the signaling system, which directly affects the punctuality and operational safety of trains, serving as the basis for achieving train FAO ...
Qiguang HUANG, Yu LIANG
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research on Signaling System of City (Suburban) Railway Cross-line Operation to Intercity Railway

Chengshi guidao jiaotong yanjiu
Objective City (suburban) railways are a weak link in the four-network integrated development of rail transit system in China. There is currently no unified understanding regarding their functional positioning and passenger flow demands.
Xiangfei DENG
doaj   +1 more source

Research on Data Platform of Urban Rail Signaling Intelligent Operation and Maintenance System

Kongzhi Yu Xinxi Jishu, 2021
Aiming at the problem of massive data processing in the construction and application of urban rail signaling intelligent operation and maintenance system, this paper studies a data platform of urban rail signaling intelligent operation and maintenance ...
DENG Yongqi, YANG Jiang, YANG Yibin
doaj