Results 101 to 110 of about 19,728,514 (315)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Emergence of macroscopic simplicity from the Tumor Necrosis Factor-alpha signaling dynamics [PDF]
, 2011 The Tumor Necrosis Factor-α (TNF-α), a cytokine produced during the innate immune response to invading pathogens, is involved in numerous fundamental cellular processes.
Vincent Piras +4 more
core
Large-Scale Signaling Network Reconstruction
, 2012 Reconstructing the topology of a signaling network by means of RNA interference (RNAi) technology is an underdetermined problem especially when a single gene in the network is knocked down or observed. In addition, the exponential search space limits the
Kavurucu, Yusuf +4 more
core +1 more source
Evolving artificial cell signaling networks using molecular classifier systems [PDF]
, 2006 Nature is a source of inspiration for computational techniques which have been successfully applied to a wide variety of complex application domains. In keeping with this we examine Cell Signaling Networks (CSN) which are chemical networks responsible ...
James Decraene +5 more
core +2 more sources
Analysis of Train Signaling System Safety Distance
Chengshi guidao jiaotong yanjiu[Objective] The current calculation of safety distance in the moving block signaling system does not consider adverse working conditions such as faults and low adhesion coefficients, resulting in poor authenticity and low precision in safety distance ...
Wenjie HUANG +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Preference Signaling in Matching Markets [PDF]
Many labor markets share three stylized facts: employers cannot give full attention to all candidates, candidates are ready to provide information about their preferences for particular employers, and employers value and are prepared to act on this ...
Muriel Niederle +2 more
core
Strategy for Selecting Signaling System Types for Suburban Railways
Chengshi guidao jiaotong yanjiuObjectiveThe mainstream signaling systems for suburban railways are CTCS2+ATO （Chinese train control system level 2 + automatic train operation） and CBTC （communication-based train control）.
Lin CHEN, Rui SONG, Ning DANG, Yifan QIU
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]
, 2007 Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P. +13 more
core +1 more source