Results 91 to 100 of about 19,728,514 (315)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
, 2020 Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Pia Aanstad +4 more
core +1 more source
Interferon signaling in chronic hepatitis C : mechanisms and implications for therapy [PDF]
, 2008 Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide and can lead to liver cirrhosis and hepatocellular carcinoma.
Sarasin-Filipowicz, Magdalena
core +1 more source
Thy-1, a Pathfinder Protein for the Post-genomic Era
Frontiers in Cell and Developmental Biology, 2018 Thy-1 is possibly the smallest of cell surface proteins – 110 amino acids folded into an Immunoglobulin variable domain, tethered to the outer leaflet of the cell surface membrane via just the two saturated fatty acids of its glycosylphosphatidylinositol
Roger J. Morris
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Signaling in deterministic and stochastic settings [PDF]
We contrast a standard deterministic signaling game with one where the signal-generating mechanism is stochastic. With stochastic signals a unique equilibrium emerges that involves separation and has intuitive comparative-static properties as the degree ...
Jeitschko, Thomas D., Normann, Hans-Theo
core
Construction and Application of Intelligent O&M System for Urban Rail Transit Signaling Systems
Chengshi guidao jiaotong yanjiu[Objective] In response to four major challenges faced in the development of urban rail transit O&M (operation and maintenance), Nanning Rail Transit Line 4 is taken as the practice platform to construct an intelligent O&M system for signaling system ...
YU Meng +4 more
doaj +1 more source
Research on Data Platform of Urban Rail Signaling Intelligent Operation and Maintenance System
Kongzhi Yu Xinxi Jishu, 2021 Aiming at the problem of massive data processing in the construction and application of urban rail signaling intelligent operation and maintenance system, this paper studies a data platform of urban rail signaling intelligent operation and maintenance ...
DENG Yongqi, YANG Jiang, YANG Yibin
doaj