Results 111 to 120 of about 19,728,514 (315)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Business transformation architecture project : strategic plan
, 2005 Title from p. [1] of PDF document (viewed Oct. 31, 2005).; "MAXIMUS, helping government serve the people"--P.
Ohio Administrative Knowledge System.
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Spence Revisited: Signaling and the Allocation of Individuals to Jobs [PDF]
Spence (1974a) considered a variant of his signaling model in which there are two types of jobs, and in which signaling can increase wealth by improving the allocation of individuals to jobs.
Timothy Perri
core
Effects of drought-, drought-signaling- and wet-signaling-responsive miRNAs in different pathways.
, 2016 Thickness of lines indicates the abundance of miRNAs that are involved in each pathway. Figure indicates how responsive miRNAs could be involved in physiological or morphological adaptation and finally how their actions could lead to energy diversion ...
Ehsan Mohseni Fard (422993) +6 more
core +1 more source
IEEE AccessThis paper introduces the multi-neighboring reference vector discontinuous pulse-width modulation (MNRV DPWM) with offset voltage injection methodology tailored for single-phase diode-clamped four-level PWM inverters.
Min-Sup Song
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
New-generation Signaling System Construction Scheme Based on Cloud Architecture
Chengshi guidao jiaotong yanjiu[Objective] With the theme of promoting urban rail transit information, developing intelligent system, and building 'smart urban rail' for a highly integrated urban rail transit cloud platform is the direction of technological development in the new era.
Minjie LIU, Gang WU
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source