Results 111 to 120 of about 1,678,713 (260)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
New-generation Signaling System Construction Scheme Based on Cloud Architecture
Chengshi guidao jiaotong yanjiu[Objective] With the theme of promoting urban rail transit information, developing intelligent system, and building 'smart urban rail' for a highly integrated urban rail transit cloud platform is the direction of technological development in the new era.
Minjie LIU, Gang WU
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Safety Evaluation of Urban Rail Transit Signal System Based on HAZOP and ALARP Principles
机车电传动, 2018 Safety requirements of subway signaling system in operating stage were analysed, the potential risks of evaluating and controlling the signal system based on HAZOP (Hazard and Operability Analysis) and ALARP (as Low as Reasonably Practicable) affecting ...
MO Zhigang, LUO Hanbin
doaj
Urban Rail Transit Signaling System Status Assessment Method Based on Analytic Hierarchy Process
Chengshi guidao jiaotong yanjiu[Objective] Shanghai rail transit signaling system faces challenges including large scale, complex model variations, and inconsistent operational lifespans.
WU Min, ZHANG Yu, CAO Yuan
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Research on Protection Section Setting of Urban Rail Transit Signaling System
Kongzhi Yu Xinxi Jishu, 2020 In urban rail transit, signaling system needs to set up overlap reasonably so as to meet the requirements of high speed route terminal train approaching, precise train stopping, and also to ensure driving safety.
ZHANG Datao
doaj
Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules. [PDF]
Biology (Basel), 2023 Emadi A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source