Results 131 to 140 of about 1,690,858 (268)

A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System. [PDF]

Genes (Basel)
Tang L, Zhou Z, Wang W, Li D, Hao T, Chen Y.   +5 more
europepmc   +1 more source

Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen-Glucose Deprivation through Activation of the Ca²⁺ Signaling System. [PDF]

Int J Mol Sci, 2023
Varlamova EG, Varlamova EG, Baryshev AS, Gudkov SV, Babenko VA, Plotnikov EY, Turovsky EA.   +6 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system. [PDF]

Proc Natl Acad Sci U S A
Zhu F, Castillo-Quan JI, Ogawa T, Wu Z, Ding L, Sura M, Watanabe Y, Lentschat H, Fernández-Cárdenas LP, Dag U, Beck-Sickinger A, Wang MC, Kahn CR, Blackwell TK.   +13 more
europepmc   +1 more source

Protein Tyrosine Phosphatases: A new paradigm in an old signaling system? [PDF]

Adv Cancer Res, 2021
Welsh CL, Pandey P, Ahuja LG.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia. [PDF]

Front Oncol
Wang Y, Dong X, Tao S, Chen Q, Chen Y, Zhang L, Shi Y, He Z, Yu L, Wang C.   +9 more
europepmc   +1 more source

The Interplay Among HIV, LINE-1, and the Interferon Signaling System. [PDF]

Front Immunol, 2021
Zhao X, Zhao Y, Du J, Gao P, Zhao K.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein. [PDF]

Cell Mol Life Sci
Będzińska A, Łasut-Szyszka B, Krześniak M, Gdowicz-Kłosok A, Rusin M.   +4 more
europepmc   +1 more source