Results 131 to 140 of about 31,177,116 (343)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Compatibility Implementation Plan for Xi’an Metro Line 2 Phase Ⅰ and Phase Ⅱ Project Signaling Systems

Chengshi guidao jiaotong yanjiu
[Objective] The signaling system for Xi’an Metro Line 2 Phase Ⅰ project (hereinafter referred to as Line 2) utilizes an imported system, while Phase Ⅱ adopts a domestically developed system.
SUN Hui, REN Yaping, LIANG Bo
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Overhaul and Renovation Plan for Signaling System of Shanghai Rail Transit Line 6

Chengshi guidao jiaotong yanjiu
[Objective] After years of operation, Shanghai Rail Transit Line 6 signaling system faces equipment aging and frequent failures. To enhance this system reliability, adaptability, and operational efficiency, it is imperative to develop an overhaul plan ...
WU Min, XU Yan, ZHANG Yu
doaj   +1 more source

Involvement of the Notch signaling system in alveolar bone resorption. [PDF]

Jpn Dent Sci Rev, 2023
Jakovljevic A, Nikolic N, Paternò Holtzman L, Tournier P, Gaudin A, Cordaro L, Milinkovic I.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cross-regulation in a three-component cell envelope stress signaling system of <i>Brucella</i>. [PDF]

mBio, 2023
Chen X, Alakavuklar MA, Fiebig A, Crosson S.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploration to Automatic Turn-back of CBTC Signaling

机车电传动, 2014
To implement metro vehicle automatic turn-back without human, automatic turn-back schemes based on CBTC system was studied, and automatic turn-back method from one end with ATC was introduced.
XU Juan, ZHENG LIhua, LI Hui, TANG Guoping   +3 more
doaj  

Two-Series-Connected Two-Level PWM Inverter With Three-Level Input Feature: Offset Voltage Injection and Continuous/Discontinuous Modulation Strategies

IEEE Access
This paper presents a two-series-connected two-level PWM inverter with a three-level input feature for high input-voltage applications. Unlike conventional multilevel converters such as diode-clamped inverters, the proposed topology eliminates clamping ...
Min-Sup Song
doaj   +1 more source