Results 81 to 90 of about 31,177,116 (343)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Analysis of Train Signaling System Safety Distance
Chengshi guidao jiaotong yanjiu[Objective] The current calculation of safety distance in the moving block signaling system does not consider adverse working conditions such as faults and low adhesion coefficients, resulting in poor authenticity and low precision in safety distance ...
Wenjie HUANG +3 more
doaj +1 more source
Emergence of macroscopic simplicity from the Tumor Necrosis Factor-alpha signaling dynamics [PDF]
, 2011 The Tumor Necrosis Factor-α (TNF-α), a cytokine produced during the innate immune response to invading pathogens, is involved in numerous fundamental cellular processes.
Kentaro Hayashi +4 more
core +1 more source
A polarized Ca2+, diacylglycerol, and STIM1 signaling system regulates directed cell migration
Nature Cell Biology, 2014 Ca2+ signals control cell migration by regulating forward movement and cell adhesion. However, it is not well understood how Ca2+-regulatory proteins and second messengers are spatially organized in migrating cells.
Feng-Chiao Tsai +6 more
semanticscholar +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Sequential pattern formation governed by signaling gradients
, 2016 Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of ...
Jörg, David J. +2 more
core +1 more source
PLoS ONE, 2014 The β1-adrenergic signaling system plays an important role in the functioning of cardiac cells. Experimental data shows that the activation of this system produces inotropy, lusitropy, and chronotropy in the heart, such as increased magnitude and ...
V. Bondarenko
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Plant Physiology, 2014 Phylogenetic analysis of members of the two-component signaling system identifies a previously unknown subfamily of putative cytokinin receptors. The two-component signaling system—the major signaling pathway of bacteria—is found among higher eukaryotes ...
N. Gruhn +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source