Results 61 to 70 of about 1,678,713 (260)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Research on Shanghai Rail Transit Signaling System Evolution Scheme
Chengshi guidao jiaotong yanjiuObjective With the rapid development of urban rail transit, the operational volume of trains has significantly increased. The existing CBTC (communication-based train control) system can no longer meet the signaling system needs of high-density ...
WANG Lizhou
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
QoS Strategies for Wired Communication Networks in Urban Rail Transit Signaling System
Chengshi guidao jiaotong yanjiuObjective With the increase in data traffic and diversification of data types in urban rail transit signaling systems, higher demands are placed on reliability, real-time performance, and security.
XU Yongshun
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Signaling System Fully Redundant On-board Architecture Suitable for TACS
Chengshi guidao jiaotong yanjiuObjective The signaling system of Shanghai Rail Transit Line 3 and Line 4 can no longer meet the requirements of high-density and high-reliability networked operation, necessitating an upgrade to TACS (train autonomous circumambulate system).
NI Zhihao
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Chengshi guidao jiaotong yanjiu[Objective] When Shanghai Rail Transit existing lines using CBTC (communication-based train control) signaling system adopts the mainline night time storage mode, after powering up on the following day, the driver starts the train in restricted manual ...
ZHAO Hongbin
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Research on A New CBTC Signaling System Based on Train-to-train Communication
机车电传动, 2018 The new CBTC signaling system based on train-to-train communication (train-to-train signaling system) introduces the concept of train centered. Through the establishment of communication and cooperation between trains, the autonomous operation and ...
LI Lei, LIN Yunzhi, WANG Lili
doaj