Results 161 to 170 of about 1,690,858 (268)

Control of Cell Size by c-di-GMP Requires a Two-Component Signaling System in the Cyanobacterium <i>Anabaena</i> sp. Strain PCC 7120. [PDF]

Microbiol Spectr, 2023
Sun QX, Huang M, Zhang JY, Zeng X, Zhang CC.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

EVALUATION OF COMPONENTS OF THE EXTRACELLULAR PURINERGIC SIGNALING SYSTEM IN HUMAN SEPSIS. [PDF]

Shock
Lovászi M, Németh ZH, Kelestemur T, Sánchez IV, Antonioli L, Pacher P, Wagener G, Haskó G.   +7 more
europepmc   +1 more source

The c-di-AMP signaling system influences stress tolerance and biofilm formation of Streptococcus mitis. [PDF]

Microbiologyopen, 2021
Rørvik GH, Naemi AO, Edvardsen PKT, Simm R.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Clinical course and vascular endothelial growth factor signaling system expression in maxillary angiosarcoma: A case report. [PDF]

Sci Prog
Arai S, Igarashi T, Goto H, Kashima K, Sasaki T, Sakaguchi M, Fukushima N, Fujii H, Nishino H, Ito M, Kanazawa T.   +10 more
europepmc   +1 more source

Role of Purinome, A Complex Signaling System, In Glioblastoma Aggressiveness. [PDF]

Front Pharmacol, 2021
Giuliani P, Carluccio M, Ciccarelli R.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of IoTDB in Intelligent Operation and Maintenance of URT Signaling Systems

Kongzhi Yu Xinxi Jishu
Continually expanding signaling system equipment in urban rail transit (URT) imposes significantly increased demands for collecting, processing, and storing operation and maintenance (O&M) data, including processing data from approximately 300 000 ...
DENG Yongqi, YANG Jiang, YANG Yibin
doaj  

The involvement of the dysfunctional insulin receptor signaling system in long COVID patients with diabetes and chronic pain and its implications for the clinical management using taVNS. [PDF]

Front Pain Res (Lausanne)
Li R, Liu W, Liu D, Jin X, Wang S.
europepmc   +1 more source