Results 181 to 190 of about 31,177,116 (343)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen-Glucose Deprivation through Activation of the Ca²⁺ Signaling System. [PDF]

Int J Mol Sci, 2023
Varlamova EG, Varlamova EG, Baryshev AS, Gudkov SV, Babenko VA, Plotnikov EY, Turovsky EA.   +6 more
europepmc   +1 more source

Transmembrane signalling systems.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1984
The three major strategies for transmembrane signalling at the plasma membrane level involve either second messengers, ion channels or receptor-mediated endocytosis. Two second-messenger types of transmembrane signalling systems have been analyzed: the adenylate cyclase and protein kinase C systems. Both are triggered by a variety of biological signals
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System. [PDF]

Genes (Basel)
Tang L, Zhou Z, Wang W, Li D, Hao T, Chen Y.   +5 more
europepmc   +1 more source

Identification of an allatostatin C signaling system in mollusc Aplysia. [PDF]

Sci Rep, 2022
Jiang HM, Yang Z, Xue YY, Wang HY, Guo SQ, Xu JP, Li YD, Fu P, Ding XY, Yu K, Liu WJ, Zhang G, Wang J, Zhou HB, Susswein AJ, Jing J.   +15 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system. [PDF]

Proc Natl Acad Sci U S A
Zhu F, Castillo-Quan JI, Ogawa T, Wu Z, Ding L, Sura M, Watanabe Y, Lentschat H, Fernández-Cárdenas LP, Dag U, Beck-Sickinger A, Wang MC, Kahn CR, Blackwell TK.   +13 more
europepmc   +1 more source

G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner. [PDF]

Front Physiol, 2023
Guthrie GL, Almutlaq RN, Sugahara S, Butt MK, Brooks CR, Pollock DM, Gohar EY.   +6 more
europepmc   +1 more source

Signaling via the NFκB system

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2016
S. Mitchell, Jesse D. Vargas, A. Hoffmann   +2 more
semanticscholar   +1 more source