Results 131 to 140 of about 191,753 (296)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparing Patterns of Natural Selection across Species Using Selective Signatures [PDF]

, 2009
Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what ...
Shapiro, Jesse
core  

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparing Patterns of Natural Selection Across Species Using Selective Signatures [PDF]

, 2007
Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what ...
Shapiro, B. Jesse
core  

Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures

, 2011
Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers.
Pusztai, Lajos, Lajos Pusztai, Schmidt Marcus, Karn, Thomas, Lars Hanker, Holtrich Uwe, Ruckhäberle Eugen, Volkmar Müller, Liedtke, Cornelia, Karn Thomas, Shiang Christine Y., Rody Achim, Gätje, Regine, Solbach Christine, Eugen Ruckhäberle, Pusztai Lajos, Müller, Volkmar, Cornelia Liedtke, Rody, Achim, Ahr Andre, Ruckhäberle, Eugen, Marcus Schmidt, Christine Y Shiang, Solbach, Christine, Gaetje Regine, Ahr, André, Andre Ahr, Thomas Karn, Hanker Lars, Achim Rody, Schmidt, Marcus, Shiang, Christine Y., Hanker, Lars, Takayuki Iwamoto, Holtrich, Uwe, Iwamoto Takayuki, Manfred Kaufmann, Liedtke Cornelia, Uwe Holtrich, Christine Solbach, Müller Volkmar, Iwamoto, Takayuki, Kaufmann Manfred, Kaufmann, Manfred, Regine Gaetje   +44 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Signatures of Selection for Intramuscular Fat in Duroc Pigs

, 2015
Intramuscular fat (IMF) content is an important trait affecting the quality of pork. Two Duroc populations (Iowa and Spain) selected for IMF were used to identify signatures of selection associated with IMF. The effects of selection were analyzed between
Kim, Eui-Soo, Ros-Frixedes, Roger, Baas, Thomas, Estany, Joan, Rothschild, Max   +4 more
core   +1 more source