Results 111 to 120 of about 191,753 (296)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits

Scientific Reports
The Sahiwal are among the most prominent international transboundary dairy cattle distributed in large numbers between India and Pakistan. With the elapse of more than seven decades after the independence and limited cross-border exchange of Sahiwal ...
Lal Muansangi, Jigyasha Tiwari, Irusappan Ilayaraja, Ishmeet Kumar, Jayesh Vyas, Anil Chitra, Sanchit Pal Singh, Pritam Pal, Gopal Gowane, A. K. Mishra, Anupama Mukherjee, Sabyasachi Mukherjee   +11 more
doaj   +1 more source

Signatures of positive selection after the introduction of genomic selection in the Finnish Ayrshire population

: The Finnish Ayrshire (FAY) belongs to the Nordic Red breeds and is characterized by high milk yield, high milk components, good fertility, and functional conformation. The FAY breeding program is based on genomic selection.
Uimari, Pekka, Katri Sarviaho, Pekka Uimari, Martikainen, Katja, Katja Martikainen, Sarviaho, Katri Johanna   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Detecting signatures of pathogen-mediated selection using population genomics

, 2018
This study used RAD-sequencing of Arabidopsis lyrata individuals sampled from across the range of two subspecies, A.l. lyrata (N.American) and A.l .petraea (European), to determine genome-wide patterns of polymorphism and genetic structure in this ...
Koch, Marcus A., Holub, Eric B., Mable, Barbara K., Vergeer, P., Buckley, James   +4 more
core   +2 more sources

Mapping signatures of positive selection in the genome of livestock

, 2014
Human driven selection during domestication and subsequent breed formation and breeding has left detectable signatures within the genome of livestock breeds.
Qanbari, Saber, Simianer, Henner
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Revealing the selection history of adaptive loci using genome-wide scans for selection: an example from domestic sheep

BMC Genomics, 2018
Background One of the approaches to detect genetics variants affecting fitness traits is to identify their surrounding genomic signatures of past selection.
Christina Marie Rochus, Flavie Tortereau, Florence Plisson-Petit, Gwendal Restoux, Carole Moreno-Romieux, Gwenola Tosser-Klopp, Bertrand Servin   +6 more
doaj   +1 more source