Results 101 to 110 of about 191,753 (296)

Luzhong mutton sheep: inbreeding and selection signatures

Journal of Animal Science and Technology, 2020
Intense artificial selection has been imposed to Luzhong mutton sheep population in the past years. Improvements on growth and reproductive performance are two breeding goals in the present herd. Although some progresses were phenotypically observed possibly due to inbreeding induced by strong selection in terms of these traits, the genomic evaluation ...
Lin Tao, Xiaoyun He, Fengyan Wang, Yingjie Zhong, Linxiang Pan, Xiangyu Wang, Shangquan Gan, Ran Di, Mingxing Chu   +8 more
openaire   +4 more sources

Genetic diversity and selection signatures in sheep breeds

Natural and artificial selection in domesticated animals can cause specific changes in genomic regions known as selection signatures. Our study used the integrated haplotype score (iHS) and Tajima’s D tests within non-overlapping windows of 100 kb to ...
Watanabe, Rafael Nakamura [UNESP], Rodrigues, Julia Lisboa [UNESP], Berry, Donagh Pearse, Buzanskas, Marcos Eli [UNESP], Munari, Danísio Prado [UNESP], Braga, Larissa Graciano [UNESP], Schenkel, Flávio Schramm   +6 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Genomic signatures of environmental adaptation in Danzhou chickens

BMC Genomics
Background Danzhou chicken (DZC) is a native chicken breed endemic to Hainan Island, which is renowned for its superior meat quality and strong disease resistance.
X. F. Xie, J. W. Fan, Z. Y. Wang, Z. Q. Zhong, D. Y. Pan, L. G. Shi, Q. Xiao, G. Y. Hou   +7 more
doaj   +1 more source

Characterisation of runs of homozygosity and inbreeding coefficients in the red-brown Korean native chickens [PDF]

Animal Bioscience
Objective The analysis of runs of homozygosity (ROH) has been applied to assess the level of inbreeding and identify selection signatures in various livestock species.
John Kariuki Macharia, Jaewon Kim, Minjun Kim, Eunjin Cho, Jean Pierre Munyaneza, Jun Heon Lee   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Signatures of selection for resistance to Haemonchus contortus in sheep and goats

BMC Genomics, 2019
Background Gastrointestinal nematode infection (GNI) is the most important disease affecting the small ruminant industry in U.S. The environmental conditions in the southern United States are ideal for the survival of the most pathogenic gastrointestinal
Zaira M. Estrada-Reyes, Yoko Tsukahara, Rodrigo R. Amadeu, Arthur L. Goetsch, Terry A. Gipson, Tilahun Sahlu, Richard Puchala, Zaisen Wang, Steve P. Hart, Raluca G. Mateescu   +9 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Strong signatures of selection in the domestic pig genome [PDF]

, 2012
Domestication of wild boar (Sus scrofa) and subsequent selection have resulted in dramatic phenotypic changes in domestic pigs for a number of traits, including behavior, body composition, reproduction, and coat color.
Barrio, Alvaro Martinez, Fredholm, M., Jern, Patric, Andersson, Leif,, Megens, H. -J, Groenen, Martien A.M., Archibald, A. L., Sayyab, Shumaila, Maqbool, K., Megens, H.J.W.C., Carlborg, Örjan,, Jørgensen, C. B., Barrio, Alvaro Martinez,, Rubin, Carl-Johan, Rubin, C.J., Sayyab, S., Archibald, Alan L., Maqbol, K., Groenen, M.A.M., Andersson, Leif, del Barrio, J.M.G., Jern, Patric,, Jorgensen, Claus B., Rubin, Carl-Johan,, Wang, Chao, Jørgensen, Claus Bøttcher, Carlborg, Orjan, Schwochow, D., Megens, Hendrik-Jan, Schwochow, Doreen, Groenen, M. A. M., Wang, Chao,, Fredholm, Merete, Groenen, Martien A. M., Maqbool, Khurram   +34 more
core   +1 more source