Results 81 to 90 of about 167,728,565 (254)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Selection for complex traits leaves little or no classic signatures of selection [PDF]

, 2014
BACKGROUND: Selection signatures aim to identify genomic regions underlying recent adaptations in populations. However, the effects of selection in the genome are difficult to distinguish from random processes, such as genetic drift.
Sarah J Saxton, Sunduimijid Bolormaa, Michael E Goddard, Goddard, ME, Kathryn E Kemper, Benjamin J Hayes, Kemper, KE, Bolormaa, S, Saxton, SJ, Hayes, BJ   +9 more
core   +1 more source

Genomic signatures of environmental adaptation in Danzhou chickens

BMC Genomics
Background Danzhou chicken (DZC) is a native chicken breed endemic to Hainan Island, which is renowned for its superior meat quality and strong disease resistance.
X. F. Xie, J. W. Fan, Z. Y. Wang, Z. Q. Zhong, D. Y. Pan, L. G. Shi, Q. Xiao, G. Y. Hou   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission

, 2014
Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 5/1/14Official website of the Connecticut Judicial Selection Commission ...

core  

Mobile qualified electronic signatures and certification on demand [PDF]

, 2006
Despite a legal framework being in place for several years, the market share of qualified electronic signatures is disappointingly low. Mobile Signatures provide a new and promising opportunity for the deployment of an infrastructure for qualified ...
Roßnagel, Heiko
core  

Detection of selection signatures in Piemontese and Marchigiana cattle, two breeds with similar production aptitudes but different selection histories [PDF]

, 2015
Background Domestication and selection are processes that alter the pattern of within- and between-population genetic variability. They can be investigated at the genomic level by tracing the so-called selection signatures.
DIMAURO, Corrado, Sorbolini, S, Valentini, A, MACCIOTTA, Nicolo' Pietro Paolo, Cellesi, M, Marras, G, GASPA, Giustino   +6 more
core   +1 more source

DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits

Scientific Reports
The Sahiwal are among the most prominent international transboundary dairy cattle distributed in large numbers between India and Pakistan. With the elapse of more than seven decades after the independence and limited cross-border exchange of Sahiwal ...
Lal Muansangi, Jigyasha Tiwari, Irusappan Ilayaraja, Ishmeet Kumar, Jayesh Vyas, Anil Chitra, Sanchit Pal Singh, Pritam Pal, Gopal Gowane, A. K. Mishra, Anupama Mukherjee, Sabyasachi Mukherjee   +11 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Recent and Ancient Signature of Balancing Selection around the S-Locus in Arabidopsis halleri and A. lyrata [PDF]

, 2013
Balancing selection can maintain different alleles over long evolutionary times. Beyond this direct effect on the molecular targets of selection, balancing selection is also expected to increase neutral polymorphism in linked genome regions, in inverse ...
Ruggiero, Maria-Valeria, Roux, Camille, Pauwels, M., Roux, Clément, Castric, Vincent, Vekemans, X., Pauwels, Maxime, M.-V., Ruggiero, Charlesworth, D., Vekemans, Xavier, Charlesworth, Deborah   +10 more
core   +1 more source