Results 71 to 80 of about 167,728,565 (254)

A Meta-Assembly of Selection Signatures in Cattle. [PDF]

, 2016
Since domestication, significant genetic improvement has been achieved for many traits of commercial importance in cattle, including adaptation, appearance and production.
Peter C Thomson, Herman W. Raadsma (123579), Raadsma, Herman W., Peter C. Thomson (317957), Herman W Raadsma, Randhawa, Imtiaz A. S., Imtiaz A S Randhawa, Mehar S Khatkar, Mehar S. Khatkar (123578), Thomson, Peter C., Khatkar, Mehar S., Imtiaz A. S. Randhawa (2591179)   +11 more
core   +1 more source

Signatures of selection for resistance to Haemonchus contortus in sheep and goats

BMC Genomics, 2019
Background Gastrointestinal nematode infection (GNI) is the most important disease affecting the small ruminant industry in U.S. The environmental conditions in the southern United States are ideal for the survival of the most pathogenic gastrointestinal
Zaira M. Estrada-Reyes, Yoko Tsukahara, Rodrigo R. Amadeu, Arthur L. Goetsch, Terry A. Gipson, Tilahun Sahlu, Richard Puchala, Zaisen Wang, Steve P. Hart, Raluca G. Mateescu   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Balancing selection and its effects on sequences in nearby genome regions. [PDF]

, 2006
Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection.
Deborah Charlesworth, Charlesworth Deborah, Charlesworth, Deborah   +2 more
core   +2 more sources

Bidirectional Selection for Body Weight on Standing Genetic Variation in a Chicken Model

G3: Genes, Genomes, Genetics, 2019
Experimental populations of model organisms provide valuable opportunities to unravel the genomic impact of selection in a controlled system. The Virginia body weight chicken lines represent a unique resource to investigate signatures of selection in a ...
Mette Lillie, Christa F. Honaker, Paul B. Siegel, Örjan Carlborg   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Purifying selection does not drive signatures of convergent local adaptation of lodgepole pine and interior spruce

BMC Evolutionary Biology, 2019
Background Lodgepole pine (Pinus contorta) and interior spruce (Picea glauca, Picea engelmannii, and their hybrids) are distantly related conifer species. Previous studies identified 47 genes containing variants associated with environmental variables in
Mengmeng Lu, Kathryn A. Hodgins, Jon C. Degner, Sam Yeaman   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Signatures of selection in tilapia revealed by whole genome resequencing

, 2015
Natural selection and selective breeding for genetic improvement have left detectable signatures within the genome of a species. Identification of selection signatures is important in evolutionary biology and for detecting genes that facilitate to ...
Jing, Wu, Lin, Haoran, Meng, Zining, Bai, Zhiyi, Wang, Le, Li, Jiale, Xia, Jun Hong, Liu, Feng, Yue, Gen Hua, Zhang, Yong, Wan, Zi Yi   +10 more
core   +1 more source