Results 91 to 100 of about 191,753 (296)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Evolution and Role of Molecular Tools in Measuring Diversity and Genomic Selection in Livestock Populations (Traditional and Up-to-Date Insights): A Comprehensive Exploration

Veterinary Sciences
Distinctive molecular approaches and tools, particularly high-throughput SNP genotyping, have been applied to determine and discover SNPs, potential genes of interest, indicators of evolutionary selection, genetic abnormalities, molecular indicators, and
Hosameldeen Mohamed Husien, Ahmed A. Saleh, Nada N. A. M. Hassanine, Amr M. A. Rashad, Mahmoud A. Sharaby, Asmaa Z. Mohamed, Heba Abdelhalim, Elsayed E. Hafez, Mohamed Osman Abdalrahem Essa, Saber Y. Adam, Ning Chen, Mengzhi Wang   +11 more
doaj   +1 more source

Bidirectional Selection for Body Weight on Standing Genetic Variation in a Chicken Model

G3: Genes, Genomes, Genetics, 2019
Experimental populations of model organisms provide valuable opportunities to unravel the genomic impact of selection in a controlled system. The Virginia body weight chicken lines represent a unique resource to investigate signatures of selection in a ...
Mette Lillie, Christa F. Honaker, Paul B. Siegel, Örjan Carlborg   +3 more
doaj   +1 more source

Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. [PDF]

, 2012
BACKGROUND: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies.
Kwadwo A. Koram (172174), Koram Kwadwo A., Oduro, AR, Wilson, Michael D, Ghansah Anita, Rogers William O., Abraham Hodgson, Ghansah, A, Dominic P. Kwiatkowski (106264), Abraham Hodgson (47097), Hodgson, A, Kirk A Rockett, Michael D Wilson, Michael D. Wilson, Kwiatkowski, DP, Kwadwo A. Koram, Oduro Abraham R., Hodgson, Abraham, Kwiatkowski, Dominic, Milligan Paul, Dominic P Kwiatkowski, William O. Rogers, Kwiatkowski Dominic P., Taane G Clark, Kirk A. Rockett, Ghansah, Anita, Taane G. Clark (106263), Rockett, KA, Anita Ghansah, Amenga-Etego Lucas, Koram, KA, Abraham R. Oduro, Dominic P. Kwiatkowski, Wilson Michael D., Rogers, William O, Taane G. Clark, Clark, Taane G, Clark, TG, Kwadwo A Koram, Abraham R. Oduro (172176), Paul Milligan (57142), Lucas Amenga-Etego, Koram, Kwadwo A, Thomas Anyorigiya (78750), Anyorigiya, Thomas, Kirk A. Rockett (138127), Paul Milligan, Rockett, Kirk A, Rogers, WO, Oduro, Abraham R, Wilson, MD, Amenga-Etego, Lucas, Anyorigiya, T, Michael D. Wilson (80451), William O. Rogers (172185), Hodgson Abraham, Milligan, Paul, Lucas Amenga-Etego (172180), Thomas Anyorigiya, Rockett Kirk A., Clark Taane G., Milligan, P, William O Rogers, Anita Ghansah (172168), Anyorigiya Thomas, Kwiatkowski, Dominic P, Amenga-Etego, L, Abraham R Oduro   +67 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Purifying selection does not drive signatures of convergent local adaptation of lodgepole pine and interior spruce

BMC Evolutionary Biology, 2019
Background Lodgepole pine (Pinus contorta) and interior spruce (Picea glauca, Picea engelmannii, and their hybrids) are distantly related conifer species. Previous studies identified 47 genes containing variants associated with environmental variables in
Mengmeng Lu, Kathryn A. Hodgins, Jon C. Degner, Sam Yeaman   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Resequencing Composite Kazakh Whiteheaded Cattle: Insights into Ancestral Breed Contributions, Selection Signatures, and Candidate Genetic Variants

Animals
This study investigates the genetic architecture of the Kazakh Whiteheaded (KWH) cattle, applying population genetics approaches to resequenced genomes. FST analysis of 66 cattle breeds identified breeds for admixture analysis.
Aigerim K. Khamzina, Alexander V. Igoshin, Zhadyra U. Muslimova, Asset A. Turgumbekov, Damir M. Khussainov, Nikolay S. Yudin, Yessengali S. Ussenbekov, Denis M. Larkin   +7 more
doaj   +1 more source

Feature Selection and Binarization for On-Line Signature Recognition [PDF]

, 2009
The representation of a biometric trait through a set of parametric features is commonly employed in many biometric authentication systems. In order to avoid any loss of useful information, large sets of features have been defined for biometric characteristics such as signature, gait or face.
Emanuele Maiorana, Patrizio Campisi, Alessandro Neri 0001   +2 more
openaire   +3 more sources