Results 121 to 130 of about 179,602 (215)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Whole-Genome Sequencing Reveals Breed-Specific SNPs, Indels, and Signatures of Selection in Royal White and White Dorper Sheep. [PDF]

Animals (Basel)
Liao M, Kravitz A, Haak DC, Sriranganathan N, Cockrum RR.   +4 more
europepmc   +1 more source

Contrasting gene-level signatures of selection with reproductive fitness. [PDF]

Mol Ecol, 2022
Bush SJ, Murren CJ, Urrutia AO, Kover PX.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Signatures of selection with cultural interference. [PDF]

Proc Natl Acad Sci U S A
Fogarty L, Otto SP.
europepmc   +1 more source

Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing. [PDF]

BMC Genomics, 2023
Yao Z, Zhang S, Wang X, Guo Y, Xin X, Zhang Z, Xu Z, Wang E, Jiang Y, Huang Y.   +9 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Genomic Signatures of Selection Across Climate Gradients and a Geographic Mosaic of Coevolution in an Ant Social Parasite-Host System. [PDF]

Mol Biol Evol
Macit MN, Collin E, Nieto-Blazquez ME, Kever M, Litto M, Jaitner E, Pfenninger M, Feldmeyer B, Foitzik S.   +8 more
europepmc   +1 more source

A genome-wide scan to identify signatures of selection in Lueyang black -bone chicken. [PDF]

Poult Sci, 2023
Xue Z, Wang L, Tian Y, Yang Y, Li P, Yang G, Lu H, Wang S, Zeng W, Zhang T.   +9 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source