Results 121 to 130 of about 191,753 (296)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom +6 morewiley +1 more sourceIdentification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping [PDF]
, 2011 The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits.Derrien, Thomas, Tove Fall, Battaille, Géraldine, Lequarre, Anne Sophie, Ratnakumar, Abhirami, Quilez, Javier, Broad Inst Harvard & MIT, Vaysse Amaury, Eija H. Seppälä, Hansen, Mark, H., Lawley, Cindy T, Hannes Lohi, Ahonen, Saija, Seppälä Eija H., Sundberg, Katarina, Webster, Matthew Thomas,, Matthew T Webster, Hedhammar, A., Francis Galibert, Carles Vilà, Sargan, David, Farnir, Frédéric, Snaevar Sigurdsson, Hansson, Jeanette, Kyöstilä, Kaisa, Höglund, Katja, Rosengren Pielberg, Gerli, Lawley, C.T., Rothwell, Simon, Meadows, Jennifer, Kerstin Lindblad-Toh, Lathrop, Mark, null null, Galibert Francis, Illumina, USA, Hansen Mark S. T., Copeland-Stephenson, Hannah, Karlsson, E K, Aguirre-Hernandez, Jesus, Lindblad-Toh Kerstin, Galibert, Francis, Kierczak, Marcin, Catherine André, Karlsson, Elinor, K., Dukes-McEwan, Joanna, Helsinki, Philipp, Ute, Axelsson Erik, Millar, Kate, Swedish University of Agricultural Sciences, Vaysse, A., Owczarek-Lipska, Marta, Elinor K. Karlsson, Axelsson, Erik, Hansen, Mark S. T., Barrio, Álvaro Martínez, Seppälä, E.H., Fall, Tove, Bannasch, Danika, Melin, Malin, Rosengren Pielberg, G, Georges, Michel, Storengen, Linn Mari, Cindy T. Lawley, Wolf, Johanna, Kämpe, Olle, Peeters, Dominique, Gouni, Vassiliki, Bannasch, D, Andersson, Göran, Ake Hedhammar, Fieten, Hille, Dahlgren, Stina, Jens Häggström, Sigurdsson, Snaevar, Lingaas, Frode, Karlsson, Elinor K., Sigurdsson Snaevar, Sigurdsson, S., Hytönen, Marjo, Mogensen, Mette Sloth, Thomas, Anne, Lindblad-Toh, Kerstin, Massey, Jonathan, Axelsson, E., Momozawa, Yukihide, Sigurdsson, S, Fredholm Merete, Hansen, Mark S T, Danika Bannasch, Fall, Tove,, Pamplona, Marilou Ramos, Häggström, J, California Davis, Rosengren Pielberg, Gerli,, Seppälä, E H, Vilà, Carles, Harvard, Ratnakumar, A, Abhirami Ratnakumar, Lohi Hannes, Ahlgren, Kerstin, Vilà, Carles, Webster, M T, Erik Axelsson, Leegwater, Peter, Starkey, Mike, Quinnell, Rupert J, Mark S. T. Hansen, Derrien Thomas, Axelsson, Erik,, Andersson, Leif, Björnerfeldt, Susanne, Lohi, Hannes, Rennes, Mark S T Hansen, Bannasch Danika, Leeb, Tosso, Ratnakumar Abhirami, Karlsson Elinor K., Karlsson, Elinor, LUPA Consortium, Boerkamp, Kim, Pielberg, Gerli Rosengren, Bannasch, Danika L., Hendricks, Anke, Ratnakumar, A., Copenhagen, Folkhalsan Res Ctr, Finland, Webster, M.T., Derrien, T, Van Steenbeek, Frank, Hansen, M.S.T., Vaysse, Amaury, Faust, Nathalie, Häggström Jens, Hedhammar, A, Arendt, Maja, Bannasch, D., Vilà, C, Uppsala, Sweden, Ratnakumar, Abhirami,, Elinor K, André, Catherine, Courtay-Cahen, Celine, Lohi, H., Eija H Seppälä, Elinor K Karlsson, Matthew T. Webster, The LUPA Consortium, Clercx, Cécile, Zelenika, Diana, Karlsson, Elinor K, Häggström, Jens, Bonastre, Armand Sánchez, Pielberg, G.R., Karlsson, E.K., Vaysse, A, Galibert, F., Webster, Matthew Thomas, Lohi, H, Hansen, M S, Hitte, C., Vaysse, Amaury, Hansen, Mark S.T., Hitte Christophe, Rutteman, Gerard, Hitte, Christophe, Lawley, C T, Wiik, Caroline, Fall, T, Ollier, William, André Catherine, Fredholm, M., Karolinska Inst, Sweden, Lawley, Cindy, T., Thomas Derrien, Cindy T Lawley, André, C, CSIC, Boland, Anne, Lawley, Cindy T., Madsen, Majbritt Busk, Vilà Carles, Druet, Tom, Gerli Rosengren Pielberg, Lindblad-Toh, K, Christophe Hitte, Rosengren Pielberg Gerli, Nevalainen, Elisa, Amaury Vaysse, Fall Tove, Nolan, Catherine, Tengvall, Katarina, Callanan, Sean, Webster Matthew T., Seppälä, Eija H., Ljungvall, Ingrid, Johansson, Cecilia, Fredholm, Merete, Derrien, T., Lindblad-Toh, Kerstin,, Gustafsson, Susanne, Axelsson, E, Merveille, Anne Christine, Fall, T., Haggstrom, J., Mellersh, Cathryn, Webster, Matthew T., Webster, Matthew, T., Lawley Cindy T., Andre, C., Tiret, Laurent, Kennedy, Lorna; id_orcid, Hansen, M.S., Favrot, Claude, Seppälä, Eija, H., Hedhammar, Åke, Galibert, F, Chetboul, Valérie, Merete Fredholm, Hitte, C, Fredholm, M, Carlborg, Örjan, Wess, Gerhard, Catchpole, Brian, Lindblad-Toh, Kerstin, Seppälä, Eija H, Hedhammar Åke +228 morecore +1 more sourcePre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan +11 morewiley +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceNovel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia.
PLoS ONE, 2019 Genomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations.Salvatore Mastrangelo, Hussain Bahbahani, Bianca Moioli, Abulgasim Ahbara, Mohammed Al Abri, Faisal Almathen, Anne da Silva, Ibrahim Belabdi, Baldassare Portolano, Joram M Mwacharo, Olivier Hanotte, Fabio Pilla, Elena Ciani +12 moredoaj +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more source
