Results 191 to 200 of about 546,808 (280)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits. [PDF]

BMC Genomics
Pallotti S, Garcia AFR, Deiana G, Antonini M, Zhou J, Sun H, Renieri C, Napolioni V.   +7 more
europepmc   +1 more source

Assessing Genomic Diversity and Signatures of Selection in Chinese Red Steppe Cattle Using High-Density SNP Array. [PDF]

Animals (Basel), 2023
Hu M, Jiang H, Lai W, Shi L, Yi W, Sun H, Chen C, Yuan B, Yan S, Zhang J.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand. [PDF]

Immunogenetics
Schaschl H, Herzog T, Oberreiter V, Kutanan W, Jakobsson M, Larena M.   +5 more
europepmc   +1 more source

Identification of Signatures of Selection for Litter Size and Pubertal Initiation in Two Sheep Populations. [PDF]

Animals (Basel), 2022
Zhang Z, Sui Z, Zhang J, Li Q, Zhang Y, Wang C, Li X, Xing F.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Genome-wide scan for signatures of selection in Hanwoo and Angus cattle using whole-genome sequence data. [PDF]

PLoS One
Ju Kim H, Moghaddar N, Clark S, van der Werf JHJ, de Las Heras-Saldana S.   +4 more
europepmc   +1 more source

Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data. [PDF]

Animals (Basel), 2022
Zhang W, Liu L, Zhou M, Su S, Dong L, Meng X, Li X, Wang C.   +7 more
europepmc   +1 more source