Results 61 to 70 of about 39,748 (262)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The Chromatic Number of a Signed Graph [PDF]
The Electronic Journal of Combinatorics, 2016 In 1982, Zaslavsky introduced the concept of a proper vertex colouring of a signed graph $G$ as a mapping $\phi\colon V(G)\to \mathbb{Z}$ such that for any two adjacent vertices $u$ and $v$ the colour $\phi(u)$ is different from the colour $\sigma(uv)\phi(v)$, where is $\sigma(uv)$ is the sign of the edge $uv$.
Edita Mácajová +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Discrete Applied Mathematics, 1980 AbstractA class of signed digraphs which arises naturally, in the theory of sign solvable linear systems is introduced. Several results are obtained concerning the structure of such graphs. Also an application is made revealing much of the structure of matrices of sign-solvable systems.
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On net-Laplacian energy of signed graphs
Communications in Combinatorics and Optimization, 2017 A signed graph is a graph where the edges are assigned either positive or negative signs. Net degree of a signed graph is the difference between the number of positive and negative edges incident with a vertex. It is said to be net-regular if all its
Nutan G. Nayak
doaj +1 more source
On signed degrees in signed graphs [PDF]
Czechoslovak Mathematical Journal, 1994 A graph is called signed if there is a designation of its edges as either positive or negative. The signed degree of a vertex \(v\) is the number of positive edges through \(v\) less the number of negative edges through \(v\). The degree sequence consists of signed degrees of all vertices in nonincreasing order.
Chartrand, Gary +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Discrete Mathematics, 1982 AbstractColoring a signed graph by signed colors, one has a chromatic polynomial with the same enumerative and algebraic properties as for ordinary graphs. New phenomena are the interpretability only of odd arguments and the existence of a second chromatic polynomial counting zero-free colorings. The generalization to voltage graphs is outlined.
openaire +1 more source