Results 81 to 90 of about 735,632 (298)
On the Powers of Signed Graphs
, 2020 A signed graph is an ordered pair $Σ=(G,σ),$ where $G=(V,E)$ is the underlying graph of $Σ$ with a signature function $σ:E\rightarrow \{1,-1\}$. In this article, we define $n^{th}$ power of a signed graph and discuss some properties of these powers of signed graphs.
T V, Shijin, K A, Germina, K, Shahul
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
On net-Laplacian energy of signed graphs
Communications in Combinatorics and Optimization, 2017 A signed graph is a graph where the edges are assigned either positive or negative signs. Net degree of a signed graph is the difference between the number of positive and negative edges incident with a vertex. It is said to be net-regular if all its
Nutan G. Nayak
doaj +1 more source
Discrete Applied Mathematics, 1980 AbstractA class of signed digraphs which arises naturally, in the theory of sign solvable linear systems is introduced. Several results are obtained concerning the structure of such graphs. Also an application is made revealing much of the structure of matrices of sign-solvable systems.
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
On eigenspaces of some compound signed graphs
, 2016 In the theory of (simple) graphs the concepts of the line and subdivision graph (as compound graphs) are well-known. It is possible to consider them also in the context of (edge) signed graphs.
Sciriha, Irene +2 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2016 [[abstract]]In this paper we introduced a new notion S-antipodal signed graph of a signed graph and its properties are obtained. Also we give the re- lation between antipodal signed graphs and S-antipodal signed graphs.
P. Siva Kota Reddy, B. Prashanth
core