Results 71 to 80 of about 41,221 (298)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Bipartite Consensus Problems on Second-Order Signed Networks With Heterogeneous Topologies

open access: yesIEEE Access, 2020
This paper is devoted to the convergence problem for second-order signed networks that are associated with two signed graphs in the presence of heterogeneous topologies.
Jianheng Ling   +2 more
doaj   +1 more source

Signed domination numbers of directed graphs [PDF]

open access: yes, 2005
summary:The concept of signed domination number of an undirected graph (introduced by J. E. Dunbar, S. T. Hedetniemi, M. A. Henning and P. J. Slater) is transferred to directed graphs. Exact values are found for particular types of tournaments.
Zelinka, Bohdan
core   +1 more source

On composition of signed graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2012
A graph whose edges are labeled either as positive or negative is called a signed graph. In this article, we extend the notion of composition of (unsigned) graphs (also called lexicographic product) to signed graphs. We employ Kronecker product of matrices to express the adjacency matrix of this product of two signed graphs and hence find its ...
K. Augustine Germina   +1 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Signed Complete Graphs with Maximum Index

open access: yesDiscussiones Mathematicae Graph Theory, 2020
Let Γ = (G, σ) be a signed graph, where G is the underlying simple graph and σ E(G) → {−, +} is the sign function on the edges of G. The adjacency matrix of a signed graph has −1 or +1 for adjacent vertices, depending on the sign of the edges.
Akbari Saieed   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

On Cartesian Products of Signed Graphs [PDF]

open access: yesDiscrete Applied Mathematics, 2020
In this paper, we study the Cartesian product of signed graphs as defined by Germina, Hameed and Zaslavsky (2011). Here we focus on its algebraic properties and look at the chromatic number of some Cartesian products. One of our main results is the unicity of the prime factor decomposition of signed graphs.
openaire   +2 more sources

Matroids of Gain Signed Graphs

open access: yesDiscrete & Computational Geometry, 2023
13 fig., 46 pp. v2 has new Example 3.7, minor editing, 47 pp.
Laura Anderson   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

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