Results 71 to 80 of about 37,702 (263)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Eigenpairs of adjacency matrices of balanced signed graphs
Special MatricesIn this article, we study eigenvalues λ\lambda and their associated eigenvectors xx of the adjacency matrices AA of balanced signed graphs. Balanced signed graphs were first introduced and studied by Harary to handle a problem in social psychology ...
Chen Mei-Qin
doaj +1 more source
Signed Roman Edge k-Domination in Graphs
Discussiones Mathematicae Graph Theory, 2017 Let k ≥ 1 be an integer, and G = (V, E) be a finite and simple graph. The closed neighborhood NG[e] of an edge e in a graph G is the set consisting of e and all edges having a common end-vertex with e.
Asgharsharghi Leila +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Signed graphs with strong (anti-)reciprocal eigenvalue property
Special MatricesA (signed) graph is said to exhibit the strong reciprocal (anti-reciprocal) eigenvalue property (SR) (resp., (-SR)) if for any eigenvalue λ\lambda , it has 1λ\frac{1}{\lambda } (resp.,−1λ-\frac{1}{\lambda }) as an eigenvalue as well, with the same ...
Belardo Francesco, Huntington Callum
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Nonnegative signed total Roman domination in graphs
Communications in Combinatorics and Optimization, 2020 Let $G$ be a finite and simple graph with vertex set $V(G)$. A nonnegative signed total Roman dominating function (NNSTRDF) on a graph $G$ is a function $f:V(G)\rightarrow\{-1, 1, 2\}$ satisfying the conditions that (i) $\sum_{x\in N(v)}f(x)\ge 0$ for
Nasrin Dehgardi, Lutz Volkmann
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FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Discrete Applied Mathematics, 1980 AbstractA class of signed digraphs which arises naturally, in the theory of sign solvable linear systems is introduced. Several results are obtained concerning the structure of such graphs. Also an application is made revealing much of the structure of matrices of sign-solvable systems.
openaire +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source