Results 81 to 90 of about 5,524,481 (291)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Exploring hidden narratives: Conscript graffiti at the former military base of Kummersdorf

open access: yes, 2013
This article explores the cultural significance and interpretative potential of graffiti left by Soviet conscripts at Kummersdorf, a former military base in the German federal state of Brandenburg.
Merrill, Samuel,   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

When is statistical significance not significant?

open access: yesBrazilian Political Science Review, 2007
The article provides a non-technical introduction to the p value statistics. Its main purpose is to help researchers make sense of the appropriate role of the p value statistics in empirical political science research.
Dalson Britto Figueiredo Filho   +6 more
doaj  

The Semantic Shift Of Place In The Cinematic Film (The film “Platform” is an example)

open access: yesالاكاديمي
This research is concerned with studying the semantic shift of place in the cinematic film, in order to determine the new semantic and aesthetic dimensions that the shift of place from the ordinary adds.
Saad Nadhom Issa
doaj   +1 more source

Effect size

open access: yesPsychiatry and Behavioral Sciences, 2014
Statistical significance (p value) is a considerable measure when the manuscripts were reading or interpreting. On the other hand clinical importance, which is important at least as statistical significance, may not consider every time by authors or ...
Selim Kılıc
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The reporting of statistical significance in scientific journals: A reflexion

open access: yesDemographic Research, 2008
Scientific journals in most empirical disciplines have regulations about how authors should report the precision of their estimates of model parameters and other model elements.
Jan M. Hoem
doaj  

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