Results 91 to 100 of about 42,824 (215)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

Journal of Toxicology, 2014
Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity.
Mohamed A. Morsy, Salwa A. Ibrahim, Entesar F. Amin, Maha Y. Kamel, Rehab A. Rifaai, Magdy K. Hassan   +5 more
doaj   +1 more source

Sildenafil for the Treatment of Pulmonary Hypertension in Pediatric Patients [PDF]

, 2009
Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase.
Ebenroth, Eric S., Huddleston, Alice J., Knoderer, Chad A., Morris, Jennifer L.   +3 more
core   +2 more sources

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

Influence of low‐dose dopamine on exercise in fibrosing interstitial lung disease

Experimental Physiology, EarlyView.
ABSTRACT Fibrotic interstitial lung disease (FILD) is associated with dyspnoea and exercise intolerance. In other cardiorespiratory conditions, heightened carotid body (CB) chemoreflex sensitivity is associated with reduced exercise capacity. We tested the hypothesis that CB chemoreflex inhibition would improve exercise endurance time (EET) and reduce ...
Charlotte Chen, Jui‐Lin Fan, Michael Plunkett, Thalia Babbage, John Kolbe, Julian F. R. Paton, James P. Fisher   +6 more
wiley   +1 more source

The issue of recreational use of sildenafil

Journal of Education, Health and Sport
Introduction and purpose Erectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse.
Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Paulina Słomka, Edyta Gwóźdź, Dawid Konieczko, Ewa Gardocka   +9 more
doaj   +1 more source

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1247-1255, April 2026.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Methods of Assessment and Clinical Relevance of QT Dynamics [PDF]

, 2005
The dependence on heart rate of the QT interval has been investigated for many years and several mathematical formulae have been proposed to describe the QT interval/heart rate (or QT interval/RR interval) relationship. While the most popular is Bazett’s
Agata, Musialik-Lydka, Anna, Sliwinska, Beata, Sredniawa, Piotr, Jarski, Zbigniew, Kalarus   +4 more
core  

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Drug Design, Development and Therapy, 2017
Milko Radicioni,1 Chiara Castiglioni,1 Andrea Giori,2 Irma Cupone,3 Valeria Frangione,4 Stefano Rovati4 1CROSS Research S.A., Phase I Unit, Arzo, Switzerland; 2IBSA Farmaceutici Italia, Lodi, Italy; 3Bouty S.p.A., Strada Padana Superiore, Cassina De ...
Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S   +5 more
doaj  

Longitudinal 3D‐DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats

NMR in Biomedicine, Volume 39, Issue 4, April 2026.
This first application of longitudinal 3D‐DCE MRI in the RUPP model demonstrated acute perfusion deficits after RUPP that resolved rapidly with advancing gestation, consistent with the adaptive placental responses to reduced uterine blood flow. ABSTRACT Placental insufficiency is a major cause of preeclampsia and fetal growth restriction.
Fatimah M. Al Darwish, Caren M. van Kammen, Fieke Terstappen, Lindy K. Alles, Raymond M. Schiffelers, A. Titia Lely, Gustav J. Strijkers, Bram F. Coolen   +7 more
wiley   +1 more source