Results 91 to 100 of about 1,711 (245)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Virginia Woolf and the new threat of war: from narrative silence to the voice of the sybil

Revista de Filología Románica, 2017
World War I alerted many writers to the probable replica of another bloodshed in coming decades. the rise of fascism, the rearmament and the weak entente between the Western nations during the 1930s confirmed this fear and obliterated Virginia Woolf’s ...
Francisco José Cortés Vieco
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

Nanomaterials, 2017
The use of gold nanoparticles for effective gene silencing has demonstrated its potential as a tool for gene expression experiments and for the treatment of several diseases.
Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra R. Fernandes, Pedro V. Baptista   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Gender differences in face concerns and behavioral responses to romantic jealousy : A study in Thailand

, 2015
Thesis (M.A. (Language and Communication))--National Institute of Development Administration, 2015The objectives of this quantitative study are: 1) to explore gender differences in face-saving concerns and behaviors in response to romantic jealousy as ...
Chayapa Srivilas
core   +1 more source

ADMINISTRATIVE SILENCE AND GOOD ADMINISTRATION: THE PRINCIPLES OF EFFECTIVENESS AND EFFICIENCY AND THE ROLE OF THE OMBUDSMAN IN THE CONTEMPORARY LEGAL SYSTEM OF THE REPUBLIC OF SERBIA

Iustinianus Primus Law Review
Good administration within administrative procedures is based on the complete and  consistent application of prescribed principles. This paper focuses on the impact of the  principles of effectiveness and efficiency of administrative procedures as ...
Darinka Kerečki
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Tale of Two Surges

SAGE Open, 2015
This manuscript compares and contrasts the political obstacles faced by Bush and Obama when they sought to deepen U.S. involvement in the wars in Iraq and Afghanistan. I compare their efforts in three areas.
Kelly McHugh
doaj   +1 more source

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

Acta Pharmaceutica Sinica B, 2019
Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Dan Xiao, Yue Zhang, Rui Wang, Yujie Fu, Tong Zhou, Hongtao Diao, Zhixia Wang, Yuan Lin, Zhange Li, Lin Wen, Xujuan Kang, Philipp Kopylov, Dmitri Shchekochikhin, Yong Zhang, Baofeng Yang   +14 more
doaj   +1 more source