Results 71 to 80 of about 36,922 (259)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

NIKAH SUBARANG AYIE VERSUS NIKAH SYARIAH KONTESTASI SIMBOLIK BERAGAMA YANG TERKALAHKAN DI LIMA PULUH KOTA SUMATERA BARAT

Humanisma: Journal of Gender Studies, 2019
Pernikahan Subarang Ayie is a marriage that is held across the river in Lareh Sago Halaban District in which the marriage is doing illegally or siri, without any binding administration.
Aidil Alfin, Ali Rahman
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Virginia Woolf and the new threat of war: from narrative silence to the voice of the sybil

Revista de Filología Románica, 2017
World War I alerted many writers to the probable replica of another bloodshed in coming decades. the rise of fascism, the rearmament and the weak entente between the Western nations during the 1930s confirmed this fear and obliterated Virginia Woolf’s ...
Francisco José Cortés Vieco
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

ADMINISTRATIVE SILENCE AND GOOD ADMINISTRATION: THE PRINCIPLES OF EFFECTIVENESS AND EFFICIENCY AND THE ROLE OF THE OMBUDSMAN IN THE CONTEMPORARY LEGAL SYSTEM OF THE REPUBLIC OF SERBIA

Iustinianus Primus Law Review
Good administration within administrative procedures is based on the complete and  consistent application of prescribed principles. This paper focuses on the impact of the  principles of effectiveness and efficiency of administrative procedures as ...
Darinka Kerečki
doaj  

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

Nanomaterials, 2017
The use of gold nanoparticles for effective gene silencing has demonstrated its potential as a tool for gene expression experiments and for the treatment of several diseases.
Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra R. Fernandes, Pedro V. Baptista   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Tale of Two Surges

SAGE Open, 2015
This manuscript compares and contrasts the political obstacles faced by Bush and Obama when they sought to deepen U.S. involvement in the wars in Iraq and Afghanistan. I compare their efforts in three areas.
Kelly McHugh
doaj   +1 more source