Results 101 to 110 of about 36,922 (259)

The conspiracy of silence in families of the terminal oncological patients

open access: yesPsicooncologia, 2008
The subject of ‘the conspiracy of silence’ is addressed following a bio-psycho-social model and taking into account current knowledge in the fields of psychooncology and palliative care, as well as research carried out both nationally and internationally.
Mª De Los Ángeles Ruiz-benítez de Lugo   +1 more
doaj  

Modalities of Legal Protection in Cases of “administrative Silence” in Bosnia and Herzegovina

open access: yesDruštvene i humanističke studije (Online)
The modern administration achieves direct cooperation with citizens and business entities and, on the basis of the law, decides on their rights and obligations. Its legal obligation is to resolve the requests of the parties within the prescribed time limits.
Emir Mehmedović, Admir Selesković
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

The positive administrative silence in French law

open access: yes, 2019
The Law of 12 November 2013 enshrines the principle that "silence equals consent" in the French administration. Until then, the opposite was the rule: for more than a century, the silence of an administrative unit when solicited has meant dismissal of the request. This revolutionary principle has been presented by the Government as an efficient mean to
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

El Silencio Administrativo y sus Matices a la Luz de la Legislación y la Jurisprudencia en un Estado Social de Derecho

open access: yesJusticia, 2008
Para brindarles a los particulares medios idóneos para su desenvolvimiento en la sociedad, el constituyente a través del artículo 23 de la Carta Política actual, elevado a derecho fundamental, le otorga a las personas la posibilidad de impulsar la ...
Fabio César Amorocho Mart   +1 more
doaj  

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