Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
, 2009 The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W. +5 more
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Plant viral suppressors of post‐transcriptional silencing do not suppress transcriptional silencing [PDF]
The Plant Journal, 2000 SummaryHomology‐dependent gene silencing is a regulatory mechanism that limits RNA accumulation from affected loci either by suppression of transcription (transcriptional gene silencing, TGS) or by activation of a sequence‐specific RNA degradation process (post‐transcriptional gene silencing, PTGS).
Marathe, M. +7 more
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Molecular Plant-Microbe Interactions, 2008 The Tobacco mosaic virus (TMV) 126-kDa protein is a suppressor of RNA silencing previously shown to delay the silencing of transgenes in Nicotiana tabacum and N. benthamiana.
Phillip A. Harries +3 more
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Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]
, 2013 Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
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Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]
, 2015 We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi +6 more
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Bacterial pathogens encode suppressors of RNA-mediated silencing [PDF]
Genome Biology, 2008 Plant pathogenic bacteria encounter host defenses mediated by a variety of small RNAs. Bacterial suppressors of silencing that inhibit multiple steps of plant microRNA biogenesis and function have recently been identified.
Mosher, Rebecca A, Baulcombe, David C
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PLoS Pathogens, 2017 A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein ...
Fangfang Li +8 more
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Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
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Biomolecules, 2022 Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti +4 more
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Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]
, 2015 STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne +6 more
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