Results 111 to 120 of about 10,310 (224)

Metabolic effects of silibinin in the rat liver

Chemico-Biological Interactions, 2012
The flavonolignan silibinin, which is a mixture of two diastereoisomers, silybin A and silybin B, is a component of the extract obtained from the fruit and seeds of the variegated milk thistle (Silybum marianum (L.) Gaertn. (Asteraceae)), known as silymarin.
Colturato, Carina Parisoto, Constantin, Rodrigo Polimeni, Maeda, Antônio Sueiti, Constantin, Renato Polimeni, Yamamoto, Nair Seiko, Bracht, Adelar, Ishii-Iwamoto, Emy Luiza, Constantin, Jorgete   +7 more
openaire   +2 more sources

Antiviral activity of silymarin against chikungunya virus [PDF]

, 2015
Citation: Lani, R., Hassandarvish, P., Chiam, C. W., Moghaddam, E., Chu, J. J. H., Rausalu, K., . . . Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 10.
Abu Bakar, S., Chiam, C. W., Chu, J. J. H., Hassandarvish, P., Higgs, Stephen, Lani, R., Merits, A., Moghaddam, E., Rausalu, K., Vanlandingham, Dana, Zandi, K.   +10 more
core   +1 more source

Epithelial–Mesenchymal Transition (EMT) : its theranostic role in cancer progression and metastasis [PDF]

, 2014
Epithelial-mesenchymal transition (EMT) is a process by which a fully differentiated epithelial cell attains mesenchymal traits and capabilities such as motility and invasiveness. There are three types.
Baldacchino, Alexandra, Grech, Alfred
core  

Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway

Mediators of Inflammation, 2018
Inflammatory bowel disease (IBD), characterized by sustained inflammation, is a latent risk factor of colon tumorigenesis. Silibinin has been reported to be anti-inflammatory and antineoplastic, but its efficacy on colitis-associated cancer (CAC) has not
Rongjuan Zheng, Jiaheng Ma, Dan Wang, Wenxiao Dong, Sinan Wang, Tianyu Liu, Runxiang Xie, Li Liu, Bangmao Wang, Hailong Cao   +9 more
doaj   +1 more source

Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis

MedComm
Fasting, without inducing malnutrition, has been shown to have various beneficial effects, including the inhibition of tumor initiation and progression.
Biying Xiao, Yanyu Jiang, Shuying Yuan, Lili Cai, Tong Xu, Lijun Jia   +5 more
doaj   +1 more source

Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis [PDF]

, 2007
The Crown gall tumour assay (CGTA) is one of several bench top bioassays recommended for the rapid screening of plants with anti-cancer activity. The rationale for the use of the bioassay is that the tumorogenic mechanism initiated in plant tissues by ...
BT. Ramesha, G. Ravikanth, KN Ganeshaiah, R Srirama, R. Uma Shaanker   +4 more
core   +1 more source

A review for discovering hepatoprotective herbal drugs with least side effects on kidney [PDF]

, 2017
The liver is a vital organ which plays a major role in the metabolism and excretion of xenobiotics from the body, and liver disease is a worldwide health problem.
Asadi-Samani, Majid., Heidari-Soureshjani, Saeid., Luther, Tahra., Raeisi, Roya., Shirani, Majid.   +4 more
core  

Silibinin inhibits PM2.5-induced liver triglyceride accumulation through enhancing the function of mitochondrial Complexes I and II

Frontiers in Pharmacology
BackgroundThe standardized extract of milk thistle seeds, known as silibinin, has been utilized in herbal medicine for over two centuries, with the aim of safeguarding the liver against the deleterious effects of various toxic substances.
Dexin Li, Dexin Li, Dexin Li, Dexin Li, Dexin Li, Jingxin Zhang, Jingxin Zhang, Jingxin Zhang, Jingxin Zhang, Jingxin Zhang, Yuxin Jin, Yuxin Jin, Yuxin Jin, Yuxin Jin, Yuxin Jin, Yaoxuan Zhu, Yaoxuan Zhu, Yaoxuan Zhu, Yaoxuan Zhu, Yaoxuan Zhu, Xiaoqing Lu, Xiaoqing Lu, Xiaoqing Lu, Xiaoqing Lu, Xiaoqing Lu, Xinmei Huo, Xinmei Huo, Xinmei Huo, Xinmei Huo, Xinmei Huo, Chunshui Pan, Chunshui Pan, Chunshui Pan, Chunshui Pan, Lijun Zhong, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Li Yan, Li Yan, Li Yan, Li Yan, Lulu Yan, Lulu Yan, Lulu Yan, Lulu Yan, Ping Huang, Ping Huang, Ping Huang, Ping Huang, Quan Li, Quan Li, Quan Li, Quan Li, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Yin Li, Yin Li, Yin Li, Yin Li, Yin Li   +64 more
doaj   +1 more source

Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders

Drug Design, Development and Therapy
Michal Selc,1,2 Radka Macova,2,3 Andrea Babelova1,2 1Centre for Advanced Material Application, Slovak Academy of Sciences, Bratislava, Slovakia; 2Department of Nanobiology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences,
Selc M, Macova R, Babelova A
doaj  

In Vitro Co-Delivery Evaluation of Novel Pegylated Nano-Liposomal Herbal Drugs of Silibinin and Glycyrrhizic Acid (Nano-Phytosome) to Hepatocellular Carcinoma Cells

Cell Journal, 2016
Objective This study aimed to evaluate a co-encapsulated pegylated nano-liposome system based on two herbal anti-tumor drugs, silibinin and glycyrrhizic acid, for delivery to a hepatocellular carcinoma (HCC) cell line (HepG2). Materials and Methods
Ochi Mohammad Mahdi, Amoabediny Ghasem, Rezayat Seyed Mahdi, Akbarzadeh Azim, Ebrahimi Bahman   +4 more
doaj