Results 101 to 110 of about 10,310 (224)
In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
core +3 more sources
Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers
MedComm, Volume 6, Issue 12, December 2025.Gastrointestinal cancer stem cells obtain the ability of unlimited self‐renewal, drug resistance, tumorigenicity as well as tendency of metastasis. ABSTRACT Gastrointestinal cancers, including gastric, hepatic, and colorectal cancers, represent a major public health problem globally. Although the 5‐year survival rate of gastrointestinal tumors has been
Jiawen Bu +6 more
wiley +1 more source
Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]
, 2014 Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta +26 more
core +1 more source
MoleculesSilibinin is a flavonoid compound extracted from the seeds of Silybum marianum (L.) Gaertn. It has the functions of liver protection, blood-lipid reduction and anti-tumor effects.
Peihai Li +10 more
doaj +1 more source
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury [PDF]
, 2017 Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (Silybum marianum) that has anti-inflammatory, antioxidative, antifibrotic, and antitumor properties. Here, we showed that silybin protected against cisplatin-induced acute
Jialing Rao +7 more
core +1 more source
New insights toward colorectal cancer chemotherapy using natural bioactive compounds [PDF]
, 2017 Combination therapy consists in the simultaneous administration of a conventional chemotherapy drug (or sometimes, a radiotherapy protocol) together with one or more natural bioactives (usually from plant or fungal origin) of small molecular weight. This
Fernández Fernández, Javier +4 more
core +1 more source
Silibinin Attenuates Mast Cell-Mediated Anaphylaxis-Like Reactions
Biological and Pharmaceutical Bulletin, 2009 Silibinin is known to have hepatoprotective, anti-carcinogenic and anti-inflammatory effects. However, roles of silibinin in the immediate-type allergic reactions (anaphylaxis) have not fully been investigated. In the present study, we have demonstrated that silibinin attenuated mast cell-mediated anaphylaxis-like reactions involved in allergic ...
Yun Ho, Choi, Guang Hai, Yan
openaire +3 more sources
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
core +2 more sources
Neurotrophic Effects of Silibinin on Differentiation of Hair Follicle Stem Cells to Neurons [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010 Background and Objectives: Hair Follicle Bulge region due to its availability and abundance is one of the areas which is easily accessible to Multi-potent stem cells that expresses Nestin marker (neuronal stem cells protein).
Asalgoo S. (MSc)1; (PhD)2; (PhD)3; (PhD)3; (MSc)4; +5 more
doaj
Modulation of protein-protein interactions for the development of novel therapeutics [PDF]
, 2016 Protein-protein interactions (PPIs) underlie most biological processes. An increasing interest to investigate the unexplored potential of PPIs in drug discovery is driven by the need to find novel therapeutic targets for a whole range of diseases with a ...
De Bosscher, Karolien +4 more
core +2 more sources