Results 171 to 180 of about 10,310 (224)
Some of the next articles are maybe not open access.
Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats
Toxicology, 2022Lead (Pb) is an environmental neurotoxin that can lead to toxicity. It has shown that tissues can be exposed to oxidative stress in lead poisoning. Since silymarin is a natural agent with antioxidant effects, this study aimed to investigate the antioxidant and chelation effects of silibinin and nano-silibinin on the oxidative stress status in lead ...
Mojdeh, Mohammadi +3 more
openaire +2 more sources
Silibinin: a toxicologist’s herbal medicine?
Clinical Toxicology, 2022Silymarin is an herbal remedy, commonly called milk thistle, or St. Mary's Thistle, and has been used for over 2000 years. It has been available as a capsule of the plant extract in Europe since 1974 to treat hepatic disorders. To date toxicologists have relied on animal studies, human case series, or retrospective reviews to decide on its use.
openaire +2 more sources
Prostate Cancer Prevention by Silibinin
Current Cancer Drug Targets, 2004Several epigenetic alterations leading to constitutively active mitogenic and cell-survival signaling, and loss of apoptotic response are causally involved in self-sufficiency of prostate cancer (PCA) cells toward uncontrolled growth, and increased secretion of pro-angiogenic factors.
Rana P, Singh, Rajesh, Agarwal
openaire +2 more sources
Silibinin for cyclopeptide mushroom poisonings
American Journal of Health-System Pharmacy, 2012Much has been published in emergency medicine and clinical toxicology literature regarding mushroom poisoning management. However, few articles in pharmacy publications have addressed the management of such emergencies.
Daniel R, Limoges +3 more
openaire +2 more sources
Silibinin is a direct inhibitor of STAT3 [PDF]
Food and Chemical Toxicology, 2018 We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin targets STAT3. Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705).
Sara Verdura +2 more
exaly +5 more sources
Silibinin: A novel inhibitor of Aβ aggregation
Neurochemistry International, 2011 Alzheimer's disease (AD) is characterized by the abnormal aggregation of amyloid β peptide (Aβ) into extracellular fibrillar deposits known as amyloid plaque. Inhibition of Aβ aggregation is therefore viewed as a potential method to halt or slow the progression of AD.
Jianhui Liu, Yanwen Wang, Junzeng Zhang
exaly +4 more sources
Targeting silibinin in the antiproliferative pathway
Expert Opinion on Investigational Drugs, 2010Due to the failure and severe toxicity of cancer chemotherapy, silibinin, a natural flavonoid from the seeds of milk thistle, has recently received more attention for its potential anticancer and nontoxic roles in animals and humans. Silibinin has clearly demonstrated inhibition of multiple cancer cell signaling pathways, including growth inhibition ...
Lei, Li, Jin, Zeng, Ye, Gao, Dalin, He
openaire +2 more sources
Current Drug Therapy, 2021
Objectives: Multiple sclerosis (MS) is a long-lasting demyelinating inflammatory disease of the central nervous system (CNS). It has been shown that brain tissue in MS is exposed to oxidative stress during the disease period. Silymarin, a plant-derived flavonoid, can be extracted from Silybum marianum.
Yasin Ahmadi +2 more
openaire +1 more source
Objectives: Multiple sclerosis (MS) is a long-lasting demyelinating inflammatory disease of the central nervous system (CNS). It has been shown that brain tissue in MS is exposed to oxidative stress during the disease period. Silymarin, a plant-derived flavonoid, can be extracted from Silybum marianum.
Yasin Ahmadi +2 more
openaire +1 more source