Results 181 to 190 of about 10,310 (224)

The binding of silibinin to ERp57

Chemico-Biological Interactions, 2014
The flavonoid silibinin is known to intervene in many cellular processes involved in a variety of pathologies, thus appearing a promising therapeutic tool. The molecular mechanisms responsible for these activities, however, have not been clearly defined, and although some of its interactions with proteins have been identified, the relative affinities ...
GRILLO, CATERINA, CHICHIARELLI, Silvia, Gaucci E, ALTIERI, Fabio, TURANO, Carlo, CERVONI, Laura   +5 more
openaire   +3 more sources

Cisplatin nephrotoxicity and protection by silibinin

Nephrology Dialysis Transplantation, 1996
The anticancer drug cisplatin is know to have toxic side-effects on different segments of the nephron. The flavonoid silibinin has previously been shown to be protective in models of hepatotoxicity. The aim of the present study was to evaluate, whether silibinin can also ameliorate alterations in renal glomerular and tubular function and tubular ...
J, Gaedeke, L M, Fels, C, Bokemeyer, U, Mengs, H, Stolte, H, Lentzen   +5 more
openaire   +2 more sources

Targeting STAT3 with silibinin to improve cancer therapeutics

Cancer Treatment Reviews, 2017
Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a number of STAT3 inhibitors have been shown to enhance the efficacy of therapeutic agents in vitro, the majority of them have yet to enter clinical evaluation mostly because of ...
Joaquim Bosch-Barrera, Javier A Menendez
exaly   +3 more sources

Antihepatotoxic Activity of Liposomal Silibinin

BioNanoScience, 2018
The liposomal form of silibinin was obtained, and its antihepatotoxic activity in mice was studied using a model of acute toxic hepatitis caused by injection of carbon tetrachloride or paracetamol. It was shown that the use of the drug in therapy or prevention regimens leads to normalization of levels of transaminases and total protein in the blood of ...
Sergey V. Lutsenko, Tatiana I. Gromovykh, Ivan I. Krasnyuk, Ivan A. Vasilenko, Nataliya B. Feldman   +4 more
openaire   +1 more source

Neuroprotective effect of silibinin in diabetic mice

Neuroscience Letters, 2011
Diabetes mellitus is associated with a higher oxidative stress and reduced activity of the antioxidant defense system in different brain regions. Results from numerous studies reported impaired cognitive and neurochemical function in diabetic patients and streptozotocin induced diabetic rodents.
Marrazzo G, Bosco P, La Delia F, Scapagnini G, DI GIACOMO, Claudia, Malaguarnera M, GALVANO, Fabio, Nicolosi A, LI VOLTI, Giovanni   +8 more
openaire   +4 more sources

Silibinin attenuates allergic airway inflammation in mice

Biochemical and Biophysical Research Communications, 2012
Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-κB) pathway.
Yun Ho, Choi, Guang Yu, Jin, Hui Shu, Guo, Hong Mei, Piao, Liang chang, Li, Guang Zhao, Li, Zhen Hua, Lin, Guang Hai, Yan   +7 more
openaire   +2 more sources

Preparation and Pharmacological Evaluation of Silibinin Liposomes

Arzneimittelforschung, 2011
The aim of the present study was to encage a drug into liposomal structures to make them more effective, safe and targeted to liver cells. The investigation deals with critical parameters controlling the formulation and evaluation of silibinin (silymarin, CAS22888-70-6) liposomes.
Hitesh, Maheshwari, Ravindra, Agarwal, Chandrashekhar, Patil, Om Prakash, Katare   +3 more
openaire   +2 more sources

Highly bioavailable silibinin nanoparticles inhibit HCV infection

Gut, 2016
Objective Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use.
Ching-Hsuan, Liu, Chun-Ching, Lin, Wen-Chan, Hsu, Chueh-Yao, Chung, Chih-Chan, Lin, Alagie, Jassey, Shun-Pang, Chang, Chen-Jei, Tai, Cheng-Jeng, Tai, Justin, Shields, Christopher D, Richardson, Ming-Hong, Yen, D Lorne J, Tyrrell, Liang-Tzung, Lin   +13 more
openaire   +2 more sources

Silibinin – A Promising New Treatment for Cancer

Anti-Cancer Agents in Medicinal Chemistry, 2010
Silymarin and its major constituent, Silibinin, are extracts from the medicinal plant Silybum marianum (milk thistle) and have traditionally been used for the treatment of liver diseases. Recently, these orally active, flavonoid agents have also been shown to exert significant anti-neoplastic effects in a variety of in vitro and in vivo cancer ...
Cheung, Catherine Wing Ying, Gibbons, Norma, Johnson, David Wayne, Nicol, David Lawrence   +3 more
openaire   +3 more sources

[Amanita poisoning--comparison of silibinin with a combination of silibinin and penicillin].

Deutsche medizinische Wochenschrift (1946), 2008
Current treatment of amatoxin poisoning includes the administration of silibinin and penicillin in combination or silibinin alone. The aim of this study was to compare both therapeutic regimes.Of 604 patients with the suspected diagnosis of amatoxin poisoning 367 were retrospectively analysed: 118 patients had received silibinin alone and 249 patients ...
M, Ganzert, N, Felgenhauer, T, Schuster, F, Eyer, C, Gourdin, T, Zilker   +5 more
openaire   +1 more source