Results 191 to 200 of about 10,310 (224)
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Nano-soldiers Ameliorate Silibinin Delivery: A Review Study
Current Drug Delivery, 2020:Flavonoids are a large group of naturally occurring compounds, which are of interest due to their great pharmacological effects and health-promoting impacts. These properties have led to their extensive application in a variety of pathological conditions, particularly cancer.
Milad Ashrafizadeh +4 more
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Comparative bioavailability of silibinin in healthy male volunteers
Int. Journal of Clinical Pharmacology and Therapeutics, 2003To study a comparative bioavailability of Liverman capsule to Legaion capsule and Silymarin tablet (which contain silibinin) in 24 healthy volunteers.Twenty-four healthy male Korean volunteers received each medicine at the silibinin dose of 120 mg in a 3 x 3 crossover study. There was a 1-week washout period among the doses.
Y C, Kim +8 more
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Overview of Silibinin anti-tumor effects
Journal of Herbal Medicine, 2020Abstract Silibinin is a major component of Silymarin mixture (Silybum marianum), which has traditionally been used to treat a wide range of liver diseases. Recently, Silibinin and its flavonoid derivatives in several in vitro models have shown a significant inhibitory effect in different types of tumors including skin, breast, lung, colon, bladder ...
Mahdi Mashhadi Akbar Boojar +2 more
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Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis
Archives of Pharmacal Research, 2007Silibinin is the major pharmacologically active compound of silymarin, the Silybum marianum fruit extract. Hepatoprotective activities of silibinin/silymarin are well-known, and recent studies demonstrated their anti-inflammatory and anti-carcinogenic effects which are due to inhibition of the transcription factor NF-kappaB. Based on this knowledge, we
Kyungwon, Min +3 more
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Biochemie und Pharmakologie von Silibinin
1996Seit Jahrhunderten hat man Extrakte aus den Bluten und Blattern der Mariendistel Silybum marianum zur Behandlung von Leberleiden verwendet. (Abb. 1)
Johann Sonnenbichler +2 more
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Chemotherapy of Amanita phalloides Poisoning with Intravenous Silibinin
Human Toxicology, 19831 A total of 18 cases of Amanita phalloides intoxication was treated by combined chemotherapy during 1980 and 1981. After attempted primary elimination of the toxin all patients received silibinin as basic therapy mainly by infusion and in two instances orally.
K, Hruby +3 more
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Silibinin: a potential old drug for cancer therapy
Expert Review of Clinical Pharmacology, 2016Silibinin is mixture of flavonolignans extracted from milk thistle and often has been used in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol and hepatitis and gall bladder disorders for its antioxidant and hepatoprotective properties.
Xing-Xing, Zhu +5 more
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Pharmacokinetic study of iodine-labeled silibinins in rat
Pharmacological Research, 2001The very low bioavailability of silibinin (silybin, SB), the main antioxidant flavonolignan of silymarin from Silybum marianum L. (Asteraceae), requires sensitive methods to study the modulation of silibinin bioavailability. To evaluate the potential for use of radiolabeled silibinin, two silibinin derivatives, separated by HPLC after iodination ((125 ...
N, Skottová +5 more
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Preclinical Evidence-based Neuroprotective Potential of Silibinin
Current Drug Research ReviewsAbstract: Neurodegeneration is an elucidating feature of many neuronal disorders including Alzheimer’s, disease, Parkinson’s disease, and cerebral ischemia. These neurodegenerative disorders are a major public health concern with high mortality and morbidity rates around the world.
Niraj Kumar Singh, Bharat Bhushan
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