Results 171 to 180 of about 5,855 (222)

Cell Membrane Hybrid Liposome-Targeted Delivery of the Heat Shock Protein 90 C-Terminal Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. [PDF]

ACS Pharmacol Transl Sci
Yang J, Lu D, Sun Y, Qiu M, Zhao T, Yan B, Wang S, Shao Z, Wang D, Li T, Xiao Q, Fu T.   +11 more
europepmc   +1 more source

Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis. [PDF]

BMC Complement Med Ther
Long L, Zhang M, Qin HZ, Xu LB, Wang BB, Wu WY, Zhu H, Lin S.   +7 more
europepmc   +1 more source

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Antioxidant properties of silybin glycosides

Phytotherapy Research, 2002
New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although ...
Pavel Kosina, Vladimír Křen, JItka Ulrichova   +2 more
exaly   +3 more sources

Chemistry of silybin

Nat. Prod. Rep., 2014
This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared.
D, Biedermann, E, Vavříková, L, Cvak, V, Křen   +3 more
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Glycosylation of silybin

Journal of the Chemical Society, Perkin Transactions 1, 1997
Silybin glycosides—23-O-β-glucoside 2b, β-galactoside 3b, β-lactoside 4b and β-maltoside 5b—have been synthesized by different methods (Helferich glycosylation, Lewis acid catalysis). Separation of two silybin diastereoisomers in the form of acetylated monoglycosides has been achieved for the first time.
Vladimír Křen, Jiří Kubisch, Petr Sedmera, Petr Halada, Věra Přikrylová, Alexandr Jegorov, Ladislav Cvak, Rolf Gebhardt, Jitka Ulrichová, Vilím Šimánek   +9 more
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Silybin, a new iron-chelating agent

Journal of Inorganic Biochemistry, 2001
Silybin, a natural occurring flavolignan isolated from the fruits of Silibum marianum, has been reported to exert antioxidant and free radical scavenging abilities. It was suggested to act also as an iron chelator. The complexation and protonation equilibria of the ferric complex of this compound have been studied by potentiometric, spectrophotometric ...
BORSARI, Marco, C. Gabbi, GHELFI, Franco, GRANDI, Romano, SALADINI, Monica, S. Severi, F. Borella   +6 more
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Biotransformation of Silybin and its Congeners

Current Drug Metabolism, 2013
Silybin and its congeners belong to a group of flavonolignans with strong biological activities. These compounds are potentially applicable in human medicine, e. g. due to their cytoprotective activity. As a part of herbal preparations available on the open market, they face the risk of potential negative drug-drug interactions.
Vladimír, Křen, Petr, Marhol, Kateřina, Purchartová, Eva, Gabrielová, Martin, Modrianský   +4 more
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Struktur des Silybins: I. Abbauversuche

Chemische Berichte, 1975
AbstractAbbauversuche führen zur Aufstellung der Wahrscheinlichen Strukturformel 1a für Silybin, eine Inhaltsstoff aus den Früchten von Silybum marianum (Familie Asteraceae). 1a ist (2R, 3R) −3,5,7‐Trihydroxy‐2‐[(2R*, 3R*)‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐hydroxymethyl‐1,4‐benzodioxan‐6‐yl]‐4‐chromanon.
Andrew Pelter, Rudolf Hänsel
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Oxidation of the Flavonolignan Silybin. In situ EPR Evidence of the Spin-Trapped Silybin Radical

Electrochimica Acta, 2016
Abstract Oxidation of natural flavonolignan silybin in an aprotic environment was studied by electrochemical methods, electron paramagnetic resonance (EPR), UV–vis and IR in situ spectroelectrochemistry and chromatographic techniques. The presence of electrochemically generated silybin radical was proven using in situ EPR spectroelectrochemistry by ...
Sokolová, R. (Romana), Tarábek, J. (Ján), Papoušková, B., Kocábová, J. (Jana), Fiedler, J. (Jan), Vacek, J., Marhol, P. (Petr), Vavříková, E. (Eva), Křen, V. (Vladimír)   +8 more
openaire   +2 more sources