Results 41 to 50 of about 19,240 (226)

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Extraction of silymarin compounds from milk thistle (Silybum marianum) seed using hot, liquid water as the solvent [PDF]

, 2002
High-value specialty chemicals are usually obtained from natural products by extracting with generally regarded as safe (GRAS) solvents. Because organic solvents are quite often used, high operating and disposal costs occur.
Alvarez Barreto, J. F., Carrier, D. Julie, Clausen, E. C.   +2 more
core   +2 more sources

Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against HO-induced Oxidative Stress in PC12 Cells

Natural Product Communications, 2016
The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in rat pheochromocytoma PC12 cells ...
Hui-Hui Jiang, Fa-Shun Yan, Liang Shen, Hong-Fang Ji   +3 more
doaj   +1 more source

A hepatitis C virus (HCV) fertőzés pathogenesise: a genetikai és az immunológiai tényezők, valamint az oxidativ stress szerepe és a kórokozó virus sajátosságai, különös tekintettel a HCV-okozta betegségekben és a tünetmentes virushordozó állapotban = Pathogenesis of hepatitis C virus (HCV) infection: the role of the genetic and immunological factors, the oxidative stress and the viral features in the HCV-related diseases and in the symptomfree virus carriers [PDF]

, 2009
Genetikai, immunológiai és környezeti tényezők potenciális szerepe krónikus hepatitis C virus (HCV) infekcióban: összehasonlitó vizsgálatok aktiv HCV hepatitises betegekben és tünetmentes "egészséges" virushordozókban. 1.
Berki, Timea, Hunyady, Béla, Kalabay, László, Nagy, Zsuzsanna, Pár, Alajos, Pár, Gabriella   +5 more
core  

Effect of silymarin in the prevention of Cisplatin nephrotoxicity, a clinical trial study. [PDF]

, 2015
BACKGROUND Reno-protective effect of Silymarin was studied in some studies mainly on rats. In some of these studies, Silymarin was shown to have positive effects on preventing or decreasing severity of Cisplatin nephrotoxicity. OBJECTIVE The aim
Geshnizjani, Sh., Hajigholami, A., Kheiri, S., Momeni, A.   +3 more
core   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

In vitroantioxidant activity of silymarin [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009
Silymarin, a known standardized extract obtained from seeds of Silybum marianum is widely used in treatment of several diseases of varying origin. In the present paper, we clarified the antioxidant activity of silymarin by employing various in vitro antioxidant assay such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH(.)) scavenging, 2,2'-azino ...
GÜLÇİN, İlhami, KOKSAL, Ekrem, SARIKAYA, Oeztuerk, BURSAL, Ercan, BEYZA, Sevim   +4 more
openaire   +3 more sources

Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin

Foods, 2020
Herbal preparations from Silybum marianum have been used since the fourth century BC in liver disease treatment and against numerous other pathologies. Consumption of silymarin containing drugs and food supplements continues to increase.
Lucie Petrásková, Kristýna Káňová, David Biedermann, Vladimír Křen, Kateřina Valentová   +4 more
doaj   +1 more source

Clinical and pharmacological applications of silymarin components at cellular and molecular level: A review [PDF]

, 2016
Silymarin, a flavonolignan from ‘milk thistle’ (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review, we discuss about its safety, efficacy and future uses
Anjomshoa, Maryam., Fallahi, Shirzad., Masoumi, Hossein., Mohammadi, Mohsen, Rostamzadeh, Ayoob.   +4 more
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