Results 41 to 50 of about 14,228 (122)

Minimally Modified HIV-1 Infection of Macaques: Development, Utility, and Limitations of Current Models

Viruses
Nonhuman primate (NHP) studies that utilize simian immunodeficiency virus (SIV) to model human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly informative research tools.
Manish Sharma, Mukta Nag, Gregory Q. Del Prete   +2 more
doaj   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Tislelizumab: Structural Innovations and Expanding Clinical Horizons in Next‐Generation PD‐1 Immunotherapy

Chronic Diseases and Translational Medicine, Volume 11, Issue 3, Page 173-185, September 2025.
The interaction of tislelizumab with PD‐1/PD‐L1 in the tumor microenvironment. Tislelizumab targets PD‐1 on T cells, blocking its interaction with PD‐L1 on tumor cells. This action is facilitated by a modified F(ab) region that limits Fc‐γ receptor binding, thereby enhancing the antitumor immune response. ABSTRACT Tislelizumab is a next‐generation PD‐1
Thy T. Nguyen, Bohan Zhang, Luke Zhong, Xiuyi Liang, Letao Bo   +4 more
wiley   +1 more source

Model Systems of Gammaherpesvirus Infection, Immunity, and Disease

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT Epstein‐Barr virus (EBV) and Kaposi's sarcoma‐associated herpesvirus (KSHV) are oncogenic human gammaherpesviruses (GHVs) associated with a broad spectrum of malignancies and chronic diseases. However, direct studies of these viruses in humans are limited by ethical constraints, technical challenges, and their strict species specificity.
Arundhati Gupta, Renfeng Li, Kathy Shair, Shou‐Jiang Gao   +3 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections. [PDF]

AIDS Res Hum Retroviruses
Hudson A, Kroll K, Bimber B, Hueber B, Woolley G, Reeves RK.   +5 more
europepmc   +1 more source

Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV/SHIV Infection. [PDF]

J Infect Dis
Endrias K, Sonawane S, Easley KA, Ukhueduan B, Lee M, Velu V, Amara RR, Bosinger SE, Paiardini M, Silvestri G, Mavigner M, Singh V, Chahroudi A.   +12 more
europepmc   +1 more source

Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection. [PDF]

J Immunol
Premeaux TA, Yeung ST, Johnson SD, Moar P, Byrareddy SN, Ndhlovu LC.   +5 more
europepmc   +1 more source

Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian-Human Immunodeficiency Virus. [PDF]

J Infect Dis
Diamond TL, Kapoor Y, Li F, Wan BL, Boddicker MA, Maxwell JW, Ngo W, Fontenot JA, Soileau KA, Villinger FJ, Grobler JA, Wang S, Fillgrove KL, Lange HS, Asante-Appiah E.   +14 more
europepmc   +1 more source