Results 31 to 40 of about 14,228 (122)

Dysregulated Metabolism in People Living With HIV in the Modern ART‐Era: A Systematic Review of Targeted Metabolomics Studies

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication, it does not eradicate the virus, and metabolic dysregulation persists despite treatment.
Levanco K. Asia, Du Toit Loots, Shayne Mason, Esme Jansen Van Vuren, Monray E. Williams   +4 more
wiley   +1 more source

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5

MedComm, Volume 7, Issue 6, June 2026.
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie, Sabrina Noettger, Jan Lawrenz, Sophie Stopper, Susanne Klute, Jan Münch, Dorota Kmiec, Qingxing Wang, Konstantin M. J. Sparrer, Frank Kirchhoff   +9 more
wiley   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, Volume 9, Issue 5, Page 1047-1055, May 2026.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Acute-phase innate immune responses in SIVmac239-infected Mamu-B*08+ Indian rhesus macaques may contribute to the establishment of elite control

Frontiers in Immunology
IntroductionSpontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be ...
Brandon C. Rosen, Kaitlin Sawatzki, Michael J. Ricciardi, Elise Smith, Inah Golez, Jack T. Mauter, Núria Pedreño-López, Aaron Yrizarry-Medina, Kim L. Weisgrau, Logan J. Vosler, Thomas B. Voigt, Johan J. Louw, Jennifer Tisoncik-Go, Leanne S. Whitmore, Christakis Panayiotou, Noor Ghosh, Jessica R. Furlott, Christopher L. Parks, Ronald C. Desrosiers, Jeffrey D. Lifson, Eva G. Rakasz, David I. Watkins, Michael Gale   +22 more
doaj   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Ultrasonographic Diagnosis of Bilateral Spontaneous Ovarian Hemorrhage in a 7‐Year‐Old Female Black‐and‐White Ruffed Lemur (Varecia variegata)

Veterinary Radiology &Ultrasound, Volume 67, Issue 2, March 2026.
ABSTRACT A 7‐year‐old female intact, black‐and‐white ruffed lemur (Varecia variegata) presented for acute anorexia, lethargy, and abnormal behavior. Initial radiographs were concerning for gastrointestinal ileus. Abdominal ultrasonography identified bilateral periovarian masses and a moderate volume of echogenic peritoneal effusion; no definitive blood
Alexander R. Chapple, Paula Rodriguez, Siobhan S. Rickert, Jordan Wilson, Jenessa Gjeltema   +4 more
wiley   +1 more source

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

Functionalist Oncology to Model the Contextuality of Dynamics and Treatment in Acute Myeloid Leukaemia

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
Functionalist oncology utilises edge‐weighted digraphs as a representational tool to model the mathematical functional interdependencies of disease factors. This methodology enables a conceptual and mechanistic analysis of key factors influencing therapeutic success, providing a framework that can be parameterised to explore patient‐specific treatment ...
Alexander Ehmann, Rakan Naboulsi, Martin Jädersten, Sylvain Tollis, Nikolas Herold   +4 more
wiley   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, Volume 8, Issue 12, Page 2196-2208, December 2025.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source