Results 1 to 10 of about 70 (69)
Simian Immunodeficiency Virus Infection of Chimpanzees [PDF]
Journal of Virology, 2005 (Uploaded by Plazi for the Bat Literature Project) Simian immunodeficiency viruses (SIVs) are primate lentiviruses that infect no fewer than 36 different nonhuman primate species in sub-Saharan Africa ([4][1], [9][2], [62][3]). Two of these viruses, SIVcpz from chimpanzees ( Pan troglodytes ) and SIVsmm from sooty mangabeys ( Cercocebus atys ...
Beatrice H. Hahn +2 more
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Nonpathogenic Simian Immunodeficiency Virus Infections [PDF]
Cold Spring Harbor Perspectives in Medicine, 2011 The simian immunodeficiency viruses (SIVs) are a diverse group of viruses that naturally infect a wide range of African primates, including African green monkeys (AGMs) and sooty mangabey monkeys (SMs). Although natural infection is widespread in feral populations of AGMs and SMs, this infection generally does not result in immunodeficiency.
Guido Silvestri +2 more
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Evolution of a Simian Immunodeficiency Virus Pathogen [PDF]
Journal of Virology, 1998 ABSTRACTAnalysis of disease induction by simian immunodeficiency viruses (SIV) in macaques was initially hampered by a lack of molecularly defined pathogenic strains. The first molecularly cloned SIV strains inoculated into macaques, SIVmacBK28 and SIVmacBK44 (hereafter designated BK28 and BK44, respectively), were cases in point, since they failed to ...
Michael Murphey-Corb +9 more
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Estimating the Impact of Vaccination on Acute Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections [PDF]
Journal of Virology, 2008 ABSTRACT The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection.
Miles P. Davenport +6 more
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques [PDF]
Journal of Virology, 1998 ABSTRACT To determine if a specific pathogenic threshold of plasma viral RNA could be defined irrespective of virus strain, RNA levels in the plasma of more than 50 infected rhesus macaques ( Macaca mulatta ) were measured.
Brigitte Rosenwirth +4 more
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Inactivation of simian immunodeficiency virus by hydrostatic pressure. [PDF]
Proceedings of the National Academy of Sciences, 1995 The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of inactivation depended on the time that the virus was subjected to compression as well as the level of the pressure and at 150 Mpa reached 5 log10 dilution units after approximately 10 hr.
Jurkiewicz, E. +5 more
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A model for testing the immunogenicity of simian immunodeficiency virus and simian–human immunodeficiency virus vaccine candidates in mice [PDF]
Journal of Virological Methods, 2009 HIV-1 Gag protein represents a promising target of cellular immunity-based vaccines due to its immunogenicity and high conservation among diverse viral subtypes. Development of novel and effective Gag-targeted vaccine candidates inducing CD8(+) and CD4(+) T cell responses requires large scale pre-clinical testing in a small animal model. In this report,
Zdenek Hel +3 more
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Simian Immunodeficiency Virus: A Model for NeuroAIDS
Neurobiology of Disease, 1997 In addition to its profound effects on the immune system, HIV also infects the CNS and can cause abnormalities in infected individuals ranging from mild cognitive and motor disorders to frank dementia. We have been actively investigating the molecular and cellular mechanisms underlying the CNS manifestations of lentivirus infection through the ...
Floyd E. Bloom +3 more
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Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections [PDF]
Journal of Virology, 2016 ABSTRACT The cells that are targeted by primate lentiviruses (HIV and simian immunodeficiency virus [SIV]) are of intense interest given the renewed effort to identify potential cures for HIV. These viruses have been reported to infect multiple cell lineages of hematopoietic origin, including all phenotypic and functional CD4 T ...
Vanessa M. Hirsch +2 more
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Pathogenesis of Simian Immunodeficiency Virus Pneumonia [PDF]
The American Journal of Pathology, 1998 Although many human immunodeficiency virus-infected individuals develop lymphocytic interstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not well defined. Human immunodeficiency virus-infected children with lymphocytic interstitial pneumonia have human immunodeficiency virus-specific cytotoxic T cells in ...
Darryl Carter +10 more
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