Patterns of HIV/SIV prevention and control by passive antibody immunization
Frontiers in Microbiology, 2016 Neutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals ...
Hiroyuki Yamamoto +2 more
doaj +1 more source
Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies
Frontiers in Microbiology, 2020 The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for preclinical evaluation of vaccines and novel treatment strategies.
Rajesh Thippeshappa +2 more
doaj +1 more source
Estimating the Impact of Vaccination on Acute Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections [PDF]
Journal of Virology, 2008 ABSTRACT The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection.
Petravic, J. +6 more
openaire +3 more sources
A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques [PDF]
Journal of Virology, 1998 ABSTRACT To determine if a specific pathogenic threshold of plasma viral RNA could be defined irrespective of virus strain, RNA levels in the plasma of more than 50 infected rhesus macaques ( Macaca mulatta ) were measured.
P, Ten Haaft +4 more
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Temple Monkeys and Health Implications of Commensalism, Kathmandu, Nepal
Emerging Infectious Diseases, 2006 The threat of zoonotic transmission of infectious agents at monkey temples highlights the necessity of investigating the prevalence of enzootic infectious agents in these primate populations.
Lisa Jones-Engel +9 more
doaj +1 more source
Modeling HIV-1 infection in the brain.
PLoS Computational Biology, 2020 While highly active antiretroviral therapy (HAART) is successful in controlling the replication of Human Immunodeficiency Virus (HIV-1) in many patients, currently there is no cure for HIV-1, presumably due to the presence of reservoirs of the virus. One
Colin T Barker, Naveen K Vaidya
doaj +1 more source
The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
Cell Reports, 2019 Summary: Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization.
Raiees Andrabi +19 more
doaj +1 more source
Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections [PDF]
Journal of Virology, 2016 ABSTRACT The cells that are targeted by primate lentiviruses (HIV and simian immunodeficiency virus [SIV]) are of intense interest given the renewed effort to identify potential cures for HIV. These viruses have been reported to infect multiple cell lineages of hematopoietic origin, including all phenotypic and functional CD4 T ...
Sarah R, DiNapoli +2 more
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Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved]
F1000Research, 2018 Human immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells.
Yufei Wang
doaj +1 more source
A model for testing the immunogenicity of simian immunodeficiency virus and simian–human immunodeficiency virus vaccine candidates in mice [PDF]
Journal of Virological Methods, 2009 HIV-1 Gag protein represents a promising target of cellular immunity-based vaccines due to its immunogenicity and high conservation among diverse viral subtypes. Development of novel and effective Gag-targeted vaccine candidates inducing CD8(+) and CD4(+) T cell responses requires large scale pre-clinical testing in a small animal model. In this report,
Jun, Xu +3 more
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