Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]
, 2010 No ...
Bjorkman, Pamela J., Klein, Joshua S.
core +24 more sources
Immune Control of AIDS Progression by an Adenovirus-Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus-Infected Macaques. [PDF]
MedComm (2020)This proof‐of‐concept study confirms that the GM‐CSF‐mediated adenovirus‐based SIV vaccine delivery strategy in combination with ART enhances antiviral immunity during acute infection. This strategy delays viral rebound and disease progression following ART by maintaining specific T cell responses and reducing immune activation.
He Y +14 more
europepmc +2 more sources
Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. [PDF]
, 2014 Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated.
Adamson, Lourdes +8 more
core +13 more sources
Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS
Pathogens, 2021 Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage.
Sonia Moretti +5 more
doaj +1 more source
SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model. [PDF]
PLoS Neglected Tropical Diseases, 2018 Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed.
Mehdi R M Bidokhti +6 more
doaj +1 more source
Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation. [PDF]
PLoS Pathogens, 2007 The main function attributed to the Rev proteins of immunodeficiency viruses is the shuttling of viral RNAs containing the Rev responsive element (RRE) via the CRM-1 export pathway from the nucleus to the cytoplasm.
Sabine Brandt +5 more
doaj +1 more source
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection. [PDF]
PLoS ONE, 2011 A safe, efficacious vaccine is required to stop the AIDS pandemic. Disappointing results from the STEP trial implied a need to include humoral anti-HIV-1 responses, a notion supported by RV144 trial data even though correlates of protection are unknown ...
Samir K Lakhashe +13 more
doaj +1 more source
Unique Pattern of Enzootic Primate Viruses in Gibraltar Macaques
Emerging Infectious Diseases, 2008 Because Gibraltar's macaques (Macaca sylvanus) have frequent contact with humans, we assayed 79 macaques for antibodies to enzootic primate viruses. All macaques were seronegative for herpesvirus B, simian T-cell lymphotropic virus, simian retrovirus ...
Gregory A. Engel +9 more
doaj +1 more source
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. [PDF]
, 2007 BackgroundWe reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the role of CD8+ cell-mediated immune responses in suppressing ...
Bischofberger, Norbert +10 more
core +3 more sources
Simian Immunodeficiency Virus Infection of Chimpanzees [PDF]
Journal of Virology, 2005 (Uploaded by Plazi for the Bat Literature Project) Simian immunodeficiency viruses (SIVs) are primate lentiviruses that infect no fewer than 36 different nonhuman primate species in sub-Saharan Africa ([4][1], [9][2], [62][3]). Two of these viruses, SIVcpz from chimpanzees ( Pan troglodytes ) and SIVsmm from sooty mangabeys ( Cercocebus atys ...
Paul M, Sharp +2 more
openaire +2 more sources