Patterns of HIV/SIV prevention and control by passive antibody immunization
Frontiers in Microbiology, 2016 Neutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals ...
Hiroyuki Yamamoto +2 more
doaj +1 more source
Modeling HIV-1 infection in the brain.
PLoS Computational Biology, 2020 While highly active antiretroviral therapy (HAART) is successful in controlling the replication of Human Immunodeficiency Virus (HIV-1) in many patients, currently there is no cure for HIV-1, presumably due to the presence of reservoirs of the virus. One
Colin T Barker, Naveen K Vaidya
doaj +1 more source
Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies
Frontiers in Microbiology, 2020 The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for preclinical evaluation of vaccines and novel treatment strategies.
Rajesh Thippeshappa +2 more
doaj +1 more source
Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]
, 2018 Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra +11 more
core +1 more source
Temple Monkeys and Health Implications of Commensalism, Kathmandu, Nepal
Emerging Infectious Diseases, 2006 The threat of zoonotic transmission of infectious agents at monkey temples highlights the necessity of investigating the prevalence of enzootic infectious agents in these primate populations.
Lisa Jones-Engel +9 more
doaj +1 more source
The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
Cell Reports, 2019 Summary: Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization.
Raiees Andrabi +19 more
doaj +1 more source
Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection. [PDF]
, 2016 HIV-1 disease progression is paradoxically characterized by systemic chronic immune activation and gut mucosal immune dysfunction, which is not fully defined.
Dandekar, Satya +6 more
core +1 more source
Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques
AIDS (London), 2016 Objective: Resting CD4+ T cells have been recognized as the major cell reservoir of latent HIV-1 during antiretroviral therapy (ART). Using an simian immunodeficiency virus (SIV)/macaque model for AIDS and HIV-related neurocognitive disorders we assessed
L. Gama +13 more
semanticscholar +1 more source
Estimating the Impact of Vaccination on Acute Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections [PDF]
Journal of Virology, 2008 ABSTRACT The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection.
Petravic, J. +6 more
openaire +3 more sources
Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola +3 more
core +3 more sources