Results 31 to 40 of about 89 (88)

Monkeypox Virus: WHO's Second Public Health Emergency of International Concern Within 2 Years

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
The figure shows examples of zoonotic diseases and their affected populations. The red arrows indicate the path of monkeypox virus infections first from a wild animal reservoir (rodents, squirrels) as a zoonosis mostly to children in central and west Africa, followed by the 2022/3 epidemic with human‐to‐human transmission in men having sex with men and
Harald Brüssow
wiley   +1 more source

Point‐of‐care nucleic acid testing – a step forward in controlling the HIV epidemic: A review

HIV Medicine, Volume 26, Issue 4, Page 536-545, April 2025.
Abstract Introduction The HIV/AIDS epidemic, with 85.6 million infections and 40.4 million AIDS‐related deaths globally, remains a critical public health challenge. Current diagnostic methods, primarily fourth‐generation immunoassays, have limitations due to their long window periods, and most viral load assays require centralized testing protocols ...
Suleyman Sarp Pinar, Mark Manak, Shanmugam Saravanan, Nesrina Imami, Catherine Kibirige   +4 more
wiley   +1 more source

Exploring the Utility of the Gut Microbiome as a Longitudinal Health Monitoring Tool in Sanctuary Chimpanzees (Pan troglodytes)

American Journal of Primatology, Volume 87, Issue 3, March 2025.
ABSTRACT The primary goal of captive primate management is to ensure optimal health and welfare of the animals in our care. Given that the gut microbiome interacts closely with host metabolism, immunity, and even cognition, it represents a potentially powerful tool for identifying subtle changes in health status across a range of body systems ...
Katherine R. Amato, Benjamin R. Lake, Samuel Ozminkowski, Hongmei Jiang, Madelyn Moy, Maria Luisa Savo Sardaro, Amy Fultz, Lydia M. Hopper   +7 more
wiley   +1 more source

Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques

Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Pathological accumulation of tau (pTau) contributes to various tauopathies, including Alzheimer's disease (AD), and correlates with cognitive decline. A rapid surge in tau‐targeted approaches via anti‐sense oligonucleotides, active/passive immunotherapies suggests that targeting p‐Tau is a viable strategy against tauopathies ...
Nicole M. Maphis, Jonathan Hulse, Julianne Peabody, Somayeh Dadras, Madelin J Whelpley, Manas Kandath, Colin Wilson, Sasha Hobson, Jeff Thompson, Suttinee Poolsup, Danielle Beckman, Sean P Ott, Jennifer W. Watanabe, Jodie L. Usachenko, Koen K Van Rompay, John Morrison, Reed Selwyn, Gary Rosenberg, Janice Knoefel, Bryce Chackerian, Kiran Bhaskar   +20 more
wiley   +1 more source

Status of HIV vaccine development: progress and promise

Journal of the International AIDS Society, Volume 28, Issue 5, May 2025.
Barton F. Haynes, Kevin O. Saunders, Beatrice H. Hahn, Kevin Wiehe, Lindsey R. Baden, George M. Shaw   +5 more
wiley   +1 more source

Versatile Features of an Antibody Mimetic Peptide and Its Variants

Journal of Peptide Science, Volume 31, Issue 3, March 2025.
Interaction analysis of the antibody mimetic peptide H1H3s with its target protein through cross‐linking mass spectrometry confirmed the proposed binding site. Binding and virus neutralizing properties were preserved in a proteolytically stable D‐amino acid peptide variant.
Simon Dolles, Simon Leukel, Sabrina Gensberger‐Reigl, Anette Rohrhofer, Lena Rauch‐Wirth, Kübra Kaygisiz, Christopher V. Synatschke, Jan Münch, Barbara Schmidt, Monika Pischetsrieder, Jutta Eichler   +10 more
wiley   +1 more source

Toll‐like receptor expression during inflammatory processes in human diseases

Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 1-14, March 2025.
Chronic inflammation in different illnesses triggered by pathogen‐associated molecular patterns and damage associated molecular patterns recognized by Toll‐like receptors (TLRs). Abstract Multi‐cellular organisms, including humans, have evolved immune systems as defense mechanisms against pathogens. The immune system employs the Toll‐like receptor (TLR)
Prashant K. Dhakad, Raghav Mishra, Isha Mishra   +2 more
wiley   +1 more source

Divergent HIV and Simian Immunodeficiency Virus Surveillance, Zaire

Emerging Infectious Diseases, 2005
Recent HIV infection or divergent HIV or simian immunodeficiency virus (SIV) strains may be responsible for Western blot-indeterminate results on 70 serum samples from Zairian hospital employees that were reactive in an enzyme immunoassay. Using universal polymerase chain reaction HIV-1, HIV-2, and SIV primers, we detected 1 (1.4%) HIV-1 sequence ...
Kenneth E. Robbins, Thomas M. Folks, Eugene Nzila Nzilambi, Amanda Schaefer, Michael E. St. Louis, Marcia L. Kalish, Danuta Pieniazek, Thomas C. Quinn   +7 more
openaire   +4 more sources

Central African Hunters Exposed to Simian Immunodeficiency Virus

Emerging Infectious Diseases, 2005
HIV-seronegative Cameroonians with exposure to nonhuman primates were tested for simian immunodeficiency virus (SIV) infection.
Michael Aidoo, Marcia L. Kalish, Cyrille F. Djoko, Nathan D. Wolfe, Clement B. Ndongmo, Donald S. Burke, Peter N. Fonjungo, Kenneth E. Robbins, George Alemnji, Eitel Mpoudi-Ngole, Clement Zeh, Thomas M. Folks, Janet M. McNicholl   +12 more
openaire   +4 more sources

Simian immunodeficiency virus as a model of human HIV disease [PDF]

Reviews in Medical Virology, 1999
Because of strong clinical, pathological, virological and immunological analogies with HIV infection of humans, infection of macaques with SIV provides a valuable model for exploring crucial issues related to both the pathogenesis and prevention of HIV infection.
openaire   +4 more sources