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Natural Endogenous Reverse Transcription of Simian Immunodeficiency Virus
It has been demonstrated that human immunodeficiency virus type 1 (HIV-1) virions are biochemically active particles, within which reverse transcription can take place even in physiological microenvironments. This process has been termed "natural endogenous reverse transcription" (NERT).
Hui Zhang+3 more
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Pathogenesis of simian immunodeficiency virus infection. [PDF]
Linda E. Whetter+3 more
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Comparison of simian immunodeficiency virus isolates
Nature, 1988Information on the extent of genetic variability among non-human primate lentiviruses related to human immunodeficiency virus (HIV) is sorely lacking. Here we describe the isolation of two molecular clones from the simian immunodeficiency virus (SIV) and their use to derive restriction endonuclease maps of five SIV isolates from rhesus macaques and one
Michael F. Ochs+9 more
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Genetic Diversity of Simian Immunodeficiency Virus
Journal of Medical Primatology, 1989We have demonstrated that the genetic diversity of simian immunodeficiency virus from African green monkeys (SIVagm) is much greater than that observed previously for individual HIV‐1, HIV‐2, or SIVmac isolates. Extensive genetic variation among SIVagm isolates and the high prevalence of green monkey infection without disease suggest that the virus has
Y M Naidu+4 more
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Cytokines and simian immunodeficiency virus infections
Research in Immunology, 1994In summary, in terms of cytokines and SIV disease, the power of the simian model for AIDS resides in the ability with which trends in T-cell profiles and cytokine production can be sequentially monitored in blood and LN, and correlated with other functional parameters and the clinical development of AIDS.
M.G. Lewis+3 more
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Photodynamic inactivation of simian immunodeficiency virus
Journal of Virological Methods, 1989A photodynamic flow system employing a dihematoporphyrin ether (DHE) was tested for its ability to inactivate the in vitro infectivity of simian immunodeficiency virus (SICMac) at 630 +/- 5 nm with a light fluence of 5 J/cm2. Cell-free SIVMac was inactivated by photoactivated hematoporphyrin derivative in a dose-dependent fashion.
J. Leveson+8 more
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Simian immunodeficiency virus as a model of HIV pathogenesis
Springer Seminars in Immunopathology, 1997HIV and AIDS have been an ever increasingly important component of the health risks facing Man worldwide for more than a decade. The potential for a massive and crippling epidemic has prompted intense efforts to develop vaccines and antiviral therapeutics.
Reinhard Kurth, Stephen Norley
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Interstitial pneumonia in simian immunodeficiency virus infection [PDF]
AbstractInterstitial pneumonia unrelated to Pneumocystis carinii or other infections was observed histopathologically in 5 of 25 rhesus monkeys infected with simian immunodeficiency virus (SIV). The predominant lesion was lymphocytic infiltration of interalveolar septa and hyperplasia of peribronchial and perivascular lymphoid tissue ...
A. Baskerville+6 more
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Simian Immunodeficiency Virus in People
New England Journal of Medicine, 1994The simian immunodeficiency viruses (SIVs) were initially identified on the basis of antibody cross-reactivity with human immunodeficiency virus type 1 (HIV-1)1. Serum samples from macaque monkeys from Asia with AIDS-like diseases were found to have antibodies that reacted with HIV-1 antigens.
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Simian immunodeficiency virus vectors: Replication and pseudotyping
Journal of Medical Primatology, 1992We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. It was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus.
Antonito T. Panganiban, Tahir A. Rizvi
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