Results 81 to 90 of about 6,200,949 (317)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study.

open access: yesPLoS ONE, 2019
OBJECTIVE:After one previous caesarean section (CS), pregnant women can deliver by elective repeat CS or have a trial of labor which can end in a vaginal birth after caesarean (VBAC) or an unplanned CS.
Emy Vankan   +6 more
doaj   +1 more source

Generation of Almost Simple Groups

open access: yesJournal of Algebra, 1995
Let \(d(X)\) denote the minimal number of generators for a group \(X\). It is well known that any finite non-abelian simple group is 2-generated. In this paper, the authors prove that if \(G\) is a finite almost simple group, i.e. \(S\leq G\leq \text{Aut} (S)\) for a finite simple non-abelian group \(S\), then \(d(G)= \max\{2, d(G/S)\}\leq 3\) and \(d ...
DALLA VOLTA F., LUCCHINI, ANDREA
openaire   +3 more sources

Finite simple groups and localization [PDF]

open access: yesIsrael Journal of Mathematics, 2002
The purpose of this paper is to explore the concept of localization, which comes from homotopy theory, in the context of finite simple groups. We give an easy criterion for a finite simple group to be a localization of some simple subgroup and we apply it in various cases.
José L. Rodríguez   +2 more
openaire   +4 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

The exact spread of M23 is 8064 [PDF]

open access: yesInternational Journal of Group Theory, 2012
Let $G$ be a finite group. We say that $G$ has emph{spread} r if for any set of distinct non-trivial elements of $G$ $X:={x_1,ldots, x_r}subset G^{#}$ there exists an element $yin G$ with the property that $langle x_i,yrangle=G$ for every $1leq ileq r ...
B. Fairbairn
doaj  

Thin finite simple groups [PDF]

open access: yesJournal of Algebra, 1976
A group G is of characterstic 2 type if F*(M) = O,(M) for each 2-local subgroup M of G. It seems likely that in the near future the problem of determining the finite simple groups will be reduced to the determination of the characteristic 2 type groups.
openaire   +5 more sources

Demonstration of negative group delays in a simple electronic circuit

open access: yes, 2002
We present a simple electronic circuit which produces negative group delays for base-band pulses. When a band-limited pulse is applied as the input, a forwarded pulse appears at the output.
Kitano, M., Nakanishi, T., Sugiyama, K.
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

A Characterization of the Small Suzuki Groups by the Number of the Same Element Order [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2015
Suppose that  is a finite group. Then the set of all prime divisors of  is denoted by  and the set of element orders of  is denoted by . Suppose that . Then the number of elements of order  in  is denoted by  and the sizes of the set of elements with the
H. Parvizi Mosaed   +2 more
doaj  

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