Results 81 to 90 of about 6,532,487 (336)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Simplicity of skew group rings of abelian groups

, 2012
Given a group G, a (unital) ring A and a group homomorphism $\sigma : G \to \Aut(A)$, one can construct the skew group ring $A \rtimes_{\sigma} G$. We show that a skew group ring $A \rtimes_{\sigma} G$, of an abelian group G, is simple if and only if its
Öinert, Johan
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Characterization of the Small Suzuki Groups by the Number of the Same Element Order [PDF]

Journal of Sciences, Islamic Republic of Iran, 2015
Suppose that  is a finite group. Then the set of all prime divisors of  is denoted by  and the set of element orders of  is denoted by . Suppose that . Then the number of elements of order  in  is denoted by  and the sizes of the set of elements with the
H. Parvizi Mosaed, A. Iranmanesh, A. Tehranian   +2 more
doaj  

Composite Higgs and leptoquarks from a simple group

Journal of High Energy Physics, 2019
We propose a composite grand unified theory to study the anomalies in the semileptonic B decays. We show a simple group containing the custodial and Standard Model gauge symmetries, that can deliver a set of composite pseudo Nambu-Goldstone bosons: the ...
Leandro Da Rold, Federico Lamagna
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Recognition of the symplectic simple group $ PSp_4(p) $ by the order and degree prime-power graph

AIMS Mathematics
Let $ G $ be a finite group, $ \operatorname{cd}(G) $ the set of all irreducible character degrees of $ G $, and $ \rho(G) $ the set of all prime divisors of integers in $ \operatorname{cd}(G) $. For a prime $ p $ and a positive integer $ n $, let $ n_p $
Chao Qin , Yu Li, Zhongbi Wang , Guiyun Chen   +3 more
doaj   +1 more source

Non-simple localizations of finite simple groups

Journal of Algebra, 2006
10 ...
Rodríguez, José L., Scherer, Jérôme, Viruel, Antonio   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source