Results 71 to 80 of about 4,594,222 (312)

Comprehensive Analysis of Simple Sequence Repeats in Pre-miRNAs [PDF]

Molecular Biology and Evolution, 2010
Simple sequence repeats (SSRs) are tandem repeat units of 1-6 bp that are identified in various complete sequences. However, the distribution, nature, and origination of SSRs in pre-miRNAs, which are characteristic stem-loop sequences and are finally processed into ∼22 nt functional miRNAs contributing to regulate several biological processes, are ...
Ming, Chen, Zhongyang, Tan, Guangming, Zeng, Jun, Peng   +3 more
openaire   +2 more sources

Comparative (computational) analysis of the DNA methylation status of trinucleotide repeat expansion diseases [PDF]

, 2013
Copyright © 2013 Mohammadmersad Ghorbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is ...
Pook, MA, Simon J. E. Taylor, Mohammadmersad Ghorbani, Ghorbani, M, Annette Payne, Taylor, SJE, Mark A. Pook, Payne, A   +7 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Development of simple sequence repeat markers for Chamerion angustifolium (Onagraceae)

Applications in Plant Sciences, 2019
Premise Rosebay willowherb, or fireweed (Chamerion angustifolium: Onagraceae), has diploid, tetraploid, and hexaploid cytotypes. There are known physiological and ecological differences among the three cytotypes, but genetic differences remain ...
Rui Mi, Tongcheng Wang, Derek W. Dunn, Kang Huang, Baoguo Li   +4 more
doaj   +1 more source

GENETIC DIVERSITY IN WHEAT GENOTYPES USING SIMPLE SEQUENCE REPEAT (SSR) MARKERS [PDF]

Research Journal of Applied Biotechnology, 2016
A total of 73 genotypes including 65 hexaploid (Triticum aestivum L.) and 8 tetraploid (Triticum durum L) wheat varieties were used in this study. Eleven microsatellite markers were used to test the genetic diversity of wheat genotypes, yielding a ...
M. El-Rawy, S. El-Sanousy, B. Abd El-fatah, H. El-Aref, A. Taghian   +4 more
doaj   +1 more source

Genomic Distribution of Simple Sequence Repeats in Brassica rapa

Molecules and Cells, 2007
Simple Sequence Repeats (SSRs) represent short tandem duplications found within all eukaryotic organisms. To examine the distribution of SSRs in the genome of Brassica rapa ssp. pekinensis, SSRs from different genomic regions representing 17.7 Mb of genomic sequence were surveyed.
Hong, Chang Pyo, Piao, Zhong Yun, Kang, Tae Wook, Batley, Jacqueline, Yang, Tae-Jin, Hur, Yoon-Kang, Bhak, Jong, Park, Beom-Seok, Edwards, David, Lim, Yong Pyo   +9 more
openaire   +4 more sources

The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues [PDF]

, 2007
Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within intron 1 of the FXN gene, leading to reduced expression of frataxin protein.
Pook, MA, Mouro Pinto, R, Al-Mahdawi, S, Trabzuni, D, Sandi, C, S. Al-Mahdawi, D. Trabzuni, S. Lymperi, D. Varshney, O. Ismail, C. Sandi, R. M. Pinto, M. Pook   +12 more
core   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

MfSAT: Detect simple sequence repeats in viral genomes [PDF]

Bioinformation, 2011
Simple sequence repeats (SSRs) are ubiquitous short tandem repeats, which are associated with various regulatory mechanisms and have been found in viral genomes. Herein, we develop MfSAT (Multi-functional SSRs Analytical Tool), a new powerful tool which can fast identify SSRs in multiple short viral genomes and then automatically calculate the numbers ...
Ming, Chen, Zhongyang, Tan, Guangming, Zeng   +2 more
openaire   +2 more sources

Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC content [PDF]

, 2011
Dynamic expansions of toxic polyglutamine (polyQ)-encoding CAG repeats in ubiquitously expressed, but otherwise unrelated, genes cause a number of late-onset progressive neurodegenerative disorders, including Huntington disease and the spinocerebellar ...
Darren G. Monckton, Monckton, Darren G,, Monckton, D.G., Colm E. Nestor, Nestor, C.E., Nestor, Colm,, Darren G Monckton, Colm E Nestor   +7 more
core   +2 more sources