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Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats

open access: yesFrontiers in Pharmacology, 2023
Microgravity experienced during space flight is known to exert several negative effects on the learning ability and memory of astronauts. Few effective strategies are currently available to counteract these effects.
Ning Jiang   +8 more
doaj   +1 more source

Effects of Simulated Weightlessness on Metabolizing Enzymes and Pharmacokinetics of Folic Acid in SD Rats.

open access: yesBiological and Pharmaceutical Bulletin, 2021
Folic acid (FA) affect human physiology and drug metabolism. Up to now, the effect of microgravity on the pharmacokinetics of FA remains unclear.
Yang Zhang   +9 more
semanticscholar   +1 more source

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

open access: yesScientific Reports, 2021
To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity.
Dong Liang, Jing Ma, Bo Wei
doaj   +1 more source

Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation

open access: yesScientific Reports, 2018
Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences.
Muge Anil-Inevi   +6 more
doaj   +1 more source

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions

open access: yesFrontiers in Systems Neuroscience, 2015
In spite of the experience gained in human space flight since Yuri Gagarin’s historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark
Gilles eClement   +2 more
doaj   +1 more source

Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?

open access: yesLife, 2023
Space colonization represents the most insidious challenge for mankind, as numerous obstacles affect the success of space missions. Specifically, the absence of gravitational forces leads to systemic physiological alterations, with particular emphasis on
Roberto Bonanni   +4 more
doaj   +1 more source

Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles. [PDF]

open access: yesPLoS ONE, 2016
Growing cells in simulated weightlessness condition might be a highly promising new technique to maintain or generate tissue constructs in a scaffold-free manner.
Shen Zhang   +7 more
doaj   +1 more source

Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease

open access: yesFrontiers in Cell and Developmental Biology, 2020
A lack of gravity experienced during space flight has been shown to have profound effects on human physiology including muscle atrophy, reductions in bone density and immune function, and endocrine disorders.
Peta Bradbury   +7 more
doaj   +1 more source

Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity

open access: yesApplied Sciences, 2020
Since the first Apollo mission in 1969, microgravity has been linked to many alterations of astronauts’ physiology, among which immunosuppression, altered inflammation and bone loss represent relevant examples.
Marina Fava   +2 more
doaj   +1 more source

Simulating Extreme Environmental Conditions via Mental Imagery: The Case of Microgravity and Weight Estimation

open access: yesFrontiers in Psychology, 2022
Mental imagery can be used for recreating an extreme environment experience. Here we assessed whether microgravity effects over cognition, that typically occur during a space mission, may be reproduced via mental imagery.
Matteo Gatti   +3 more
doaj   +1 more source

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