Results 41 to 50 of about 1,401,410 (172)

Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease

Frontiers in Cell and Developmental Biology, 2020
A lack of gravity experienced during space flight has been shown to have profound effects on human physiology including muscle atrophy, reductions in bone density and immune function, and endocrine disorders.
Peta Bradbury, Hanjie Wu, Jung Un Choi, Alan E. Rowan, Hongyu Zhang, Kate Poole, Jan Lauko, Joshua Chou   +7 more
doaj   +1 more source

Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity

Applied Sciences, 2020
Since the first Apollo mission in 1969, microgravity has been linked to many alterations of astronauts’ physiology, among which immunosuppression, altered inflammation and bone loss represent relevant examples.
Marina Fava, Alessandro Leuti, Mauro Maccarrone   +2 more
doaj   +1 more source

YAP Inhibition Alleviates Simulated Microgravity-Induced Mesenchymal Stem Cell Senescence via Targeting Mitochondrial Dysfunction

Antioxidants, 2023
Weightlessness in space leads to bone loss, muscle atrophy, and impaired immune defense in astronauts. Mesenchymal stem cells (MSCs) play crucial roles in maintaining the homeostasis and function of the tissue.
Wenjun Lv, Xiufen Peng, Yun Tu, Yisong Shi, Guanbin Song, Qing Luo   +5 more
doaj   +1 more source

Simulating Extreme Environmental Conditions via Mental Imagery: The Case of Microgravity and Weight Estimation

Frontiers in Psychology, 2022
Mental imagery can be used for recreating an extreme environment experience. Here we assessed whether microgravity effects over cognition, that typically occur during a space mission, may be reproduced via mental imagery.
Matteo Gatti, Rocco Palumbo, Alberto Di Domenico, Nicola Mammarella   +3 more
doaj   +1 more source

Administration of Essential Phospholipids Prevents Drosophila Melanogaster Oocytes from Responding to Change in Gravity

Cells
The aim of this study was to prevent initial changes in Drosophila melanogaster oocytes under simulated weightlessness and hypergravity at the 2 g level.
Ksenia K. Gogichaeva, Irina V. Ogneva
doaj   +1 more source

The Impact of Simulated Weightlessness on Endothelium-Dependent Angiogenesis and the Role of Caveolae/Caveolin-1

Cellular Physiology and Biochemistry, 2016
Background/Aims: The potential role of caveolin-1 in modulating angiogenesis in microgravity environment is unexplored. Methods: Using simulated microgravity by clinostat, we measured the expressions and interactions of caveolin-1 and eNOS in human ...
Fei Shi, Tian-Zhi Zhao, Yong-Chun Wang, Xin-Sheng Cao, Chang-Bin Yang, Yuan Gao, Cheng-Fei Li, Jiang-Dong Zhao, Shu Zhang, Xi-Qing Sun   +9 more
doaj   +1 more source

Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

Applied Sciences, 2020
Changes in cell–matrix and cell-to-cell adhesion patterns are dramatically fostered by the microgravity exposure of living cells. The modification of adhesion properties could promote the emergence of a migrating and invasive phenotype.
Giulia Ricci, Alessandra Cucina, Sara Proietti, Simona Dinicola, Francesca Ferranti, Marcella Cammarota, Antonio Filippini, Mariano Bizzarri, Angela Catizone   +8 more
doaj   +1 more source

Human gut microbiome and metabolite dynamics under simulated microgravity

Gut Microbes, 2023
The Artificial Gravity Bed Rest – European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of artificial ...
Ana Ramos-Nascimento, Lucia Grenga, Sven-Bastiaan Haange, Alexandra Himmelmann, Franca Sabine Arndt, Yen-Tran Ly, Guylaine Miotello, Olivier Pible, Nico Jehmlich, Beatrice Engelmann, Martin von Bergen, Edwin Mulder, Petra Frings-Meuthen, Christine Elisabeth Hellweg, Jens Jordan, Ulrike Rolle-Kampczyk, Jean Armengaud, Ralf Moeller   +17 more
doaj   +1 more source

Mental imagery of object motion in weightlessness

npj Microgravity, 2021
Mental imagery represents a potential countermeasure for sensorimotor and cognitive dysfunctions due to spaceflight. It might help train people to deal with conditions unique to spaceflight.
Silvio Gravano, Francesco Lacquaniti, Myrka Zago   +2 more
doaj   +1 more source

Simulated Weightlessness Effect on Ovarian Follicular Structure and Estradiol Levels in Rats [PDF]

Iranian South Medical Journal
Background: Long-term human habitation in space, enabled by advances in space travel, may impair the function of various physiological systems. Given the critical need to maintain astronauts’ health during and after missions, this study investigated the ...
Maryam Salavatifar, Amirreza Joorabli, Nasim Hayati Roodbari   +2 more
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