Results 101 to 110 of about 3,323,835 (313)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Logarithmic sensitivity ratio elucidates thermal transport physics in multivariate thermoreflectance experiments

Fundamental Research
We mathematically derived a sensitivity-based method that identifies the thermal transport physics and parameters suitable for multivariate nonlinear fits in a frequency-domain thermoreflectance (FDTR) experiment.
Jing Tu, Md Azimul Haque, Derya Baran, Wee-Liat Ong   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Possible signature of magnetic fields related to quasi-periodic oscillation observed in microquasars

, 2017
The study of quasi-periodic oscillations (QPOs) of X-ray flux observed in the stellar-mass black hole binaries can provide a powerful tool for testing of the phenomena occurring in strong gravity regime. The high frequency (HF) QPOs usually come in pairs
Kološ, Martin, Stuchlík, Zdeněk, Tursunov, Arman   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Novel Approach in Constraining Electron Spectra in Blazar Jets: The Case of Markarian 421

, 2010
We report results from the observations of the well studied TeV blazar Mrk 421 with the Swift and the Suzaku satellites in December 2008. During the observation, Mrk 421 was found in a relatively low activity state, with the corresponding 2-10 keV flux ...
Hayashida, M., Kataoka, J., Madejski, G., Ostrowski, M., Paneque, D., Stawarz, L., Takahashi, T., Tanaka, T., Tanaka, Y. T., Ushio, M.   +9 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Small area estimation of consumption per capita expenditure under simultaneous equation Rao-Yu model

MethodsX
This article proposed a simultaneous equation model for small area estimation with random area and time-varying effects called the Simultaneous Equation Rao-Yu (SERY) model. In the context of small area estimation, many socioeconomic variables are likely
Reny Ari Noviyanti, Setiawan, Agnes Tuti Rumiati   +2 more
doaj   +1 more source

Interactive application of quadratic expansion of chi-square statistic to nonlinear curve fitting [PDF]

This report contains a detailed theoretical description of an all-purpose, interactive curve-fitting routine that is based on P. R. Bevington's description of the quadratic expansion of the Chi-Square statistic.
Badavi, F. F., Everhart, Joel L.
core   +1 more source