Results 51 to 60 of about 15,025 (256)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Approximation of weakly singular integral equations by sinc projection methods. ETNA - Electronic Transactions on Numerical Analysis

, 2020
In this paper, two numerical schemes for a nonlinear integral equation of Fredholm type with weakly singular kernel are studied. These numerical methods blend collocation, convolution, and approximations based on sinc basis functions with iterative ...
Nedaiasl, Khadijeh
core   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Numerical behaviour of multigrid methods for symmetric Sinc-Galerkin systems

, 2005
The symmetric Sinc-Galerkin method developed by Lund (Math. Comput. 1986; 47:571-588), when applied to second-order self-adjoint boundary value problems on d dimensional rectangular domains, gives rise to an N × N positive definite coefficient matrix ...
Serra-Capizzano, Stefano, Tablino Possio, C., Cristina Tablino‐Possio, Stefano Serra‐Capizzano, Tablino-Possio, Cristina, Ng, M. K., Michael K. Ng, Ng, Michael K., SERRA CAPIZZANO, STEFANO   +8 more
core   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

A sinc function analogue of chebfun

, 2011
Chebfun is an established software system for computing with functions of a real variable, but its capabilities for handling functions with singularities are limited.
Lloyd N. Trefethen, Richardson, Mark, Richardson, M, Trefethen, Lloyd, Mark Richardson, Trefethen, LN, Trefethen, Lloyd N.   +6 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Numerical method based on sinc functions for solving singularly perturbed Fredholm integro-differential equations

Boundary Value Problems
A numerical method based on sinc functions is developed and examined to approximate the solution of singularly perturbed Fredholm integro-differential equations. This method involves combining sinc basis functions with nonclassical weight functions. With
K. Mohammadi, A. Alipanah
doaj   +1 more source

Regulatory effect of the long non-coding RNA MIATNB on autophagy in trabecular meshwork cells and its mechanism [PDF]

精准医学杂志
Objective To investigate the regulatory effect of the long non-coding RNA (lncRNA) MIATNB on autop-hagy in trabecular meshwork cells and its molecular mechanism.
HOU Tianyu, YANG Xuejiao, ZHANG Jingjing, ZONG Yao, YANG Songkai, LEI Yanbei, WU Ruofei, YANG Xian
doaj   +1 more source