Results 61 to 70 of about 15,025 (256)

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity

Advanced Science, EarlyView.
This work introduces a compact, low‐cost tabletop magnetic resonance elastography platform for high‐resolution viscoelastic mapping in soft‐tissue specimens. Using this method in human colorectal liver metastases, we demonstrate fully automated biomechanical profiling of treatment response and show that heterogeneity‐based metrics outperform ...
Weijie Zhao, Lisa‐Marie Skrip, Heiko Tzschätzsch, Tom Meyer, Hossein S. Aghamiry, Alexander Arnold, Lene Änne Böhne, Jakob Jordan, Oliver Boehm, Agnes K. Boehm, Steffen Görner, Jakob Schattenfroh, Yanglei Wu, Pedro Augusto Dantas de Moraes, Johann Pratschke, Jürgen Braun, Igor M. Sauer, Jing Guo, Ingolf Sack, Karl H. Hillebrandt   +19 more
wiley   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

A Valid Dynamical Control on the Reverse Osmosis System Using the CESTAC Method

Mathematics, 2020
The aim of this study is to present a novel method to find the optimal solution of the reverse osmosis (RO) system. We apply the Sinc integration rule with single exponential (SE) and double exponential (DE) decays to find the approximate solution of the
Samad Noeiaghdam, Denis Sidorov, Alyona Zamyshlyaeva, Aleksandr Tynda, Aliona Dreglea   +4 more
doaj   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Sinc-Galerkin method and a higher-order method for a 1D and 2D time-fractional diffusion equations

Boundary Value Problems
In this article, a new numerical algorithm for solving a 1-dimensional (1D) and 2-dimensional (2D) time-fractional diffusion equation is proposed. The Sinc-Galerkin scheme is considered for spatial discretization, and a higher-order finite difference ...
Man Luo, Da Xu, Xianmin Pan
doaj   +1 more source

Sinc-Approximations of Fractional Operators: A Computing Approach

Mathematics, 2015
We discuss a new approach to represent fractional operators by Sinc approximation using convolution integrals. A spin off of the convolution representation is an effective inverse Laplace transform.
Gerd Baumann, Frank Stenger
doaj   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Numerical solution of singularly perturbed singular third order boundary value problems with nonclassical sinc method

Results in Applied Mathematics
In this paper, we employ a nonclassical sinc-collocation method to compute numerical solutions for singularly perturbed singular third-order boundary value problems prevalent in various scientific and engineering domains. Utilizing the sinc approximation
A. Alipanah, K. Mohammadi, R.M. Haji
doaj   +1 more source