Results 71 to 80 of about 14,592 (227)

Numerical exploration of pollutant transport using stochastic fractional diffusion and Karhunen-Loève expansion [PDF]

Iranian Journal of Numerical Analysis and Optimization
This study explores a fractional time-space stochastic diffusion equation for modeling pollutant concentration, incorporating Caputo fractional derivatives and fractional Laplacians to capture anomalous diffusion.
Zahra Moniri, Afshin Babaei, Behrouz Parsa Moghaddam   +2 more
doaj   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Targeting METTL16 attenuates mesangial cell viability and fibrosis in a high-glucose state by suppressing m6A modification and the expression of RAP1B

BMC Molecular and Cell Biology
Background Methyltransferase-like 16 (METTL16) is involved in regulating kidney disease progression. This study aimed to investigate the effect of METTL16 on the progression of diabetic kidney disease (DKD) and its potential mechanism. Methods SV40-MES13
Weixu Wang, Yanhong Luo
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Analytical and Numerical Treatment of Evolutionary Time-Fractional Partial Integro-Differential Equations with Singular Memory Kernels

Fractal and Fractional
Evolution equations with fractional-time derivatives and singular memory kernels are used for modeling phenomena exhibiting hereditary properties, as they effectively incorporate memory effects into their formulation.
Kamel Al-Khaled, Isam Al-Darabsah, Amer Darweesh, Amro Alshare   +3 more
doaj   +1 more source

Series Solution for Painlevé Equation II

Walailak Journal of Science and Technology, 2014
The Painlev'e equations are second order ordinary differential equations which can be grouped into six families, namely Painlev'e equation I, II,…, VI.
Fazle MABOOD, Waqar Ahmad KHAN, Ahmad Izani Md ISMAIL, Ishak HASHIM   +3 more
doaj   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

The Perturbed Dual Risk Model with Constant Interest and a Threshold Dividend Strategy

Abstract and Applied Analysis, 2013
We consider the perturbed dual risk model with constant interest and a threshold dividend strategy. Firstly, we investigate the moment-generation function of the present value of total dividends until ruin.
Fanzi Zeng, Jisheng Xu
doaj   +1 more source

Space‐Time Metasurface Antenna Enabled High‐Dimensional Electromagnetic Modulation for Intrinsic Physical Layer Security

Advanced Science, EarlyView.
The concept of high‐dimensional EM modulation using the STMA for physical layer secure communication is illustrated in figure. The STMA consists of a series of programmable unit cells, with 1‐bit reconfigurable phase states (0/π). The STMA is excited by a monochromatic continuous wave (CW) at frequency fc and controlled by a field‐programmable gate ...
Xinyu Fang, Yiqing Sun, Chenfeng Yang, Siran Wang, Zheng Xing Wang, Kaixu Wang, Geng‐Bo Wu   +6 more
wiley   +1 more source