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Clinical Perspectives of Single-Cell RNA Sequencing [PDF]

Biomolecules, 2021
The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision ...
Nayoung Kim, Hye Hyeon Eum, Hae-Ock Lee
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Advances in application of single-cell RNA sequencing in cardiovascular research

Frontiers in Cardiovascular Medicine, 2022
Single-cell RNA sequencing (scRNA-seq) provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and ...
Yue Hu, Ying Zhang, Yutong Liu, Yan Gao, Tiantian San, Xiaoying Li, Xiaoying Li, Sensen Song, Binglong Yan, Zhuo Zhao, Zhuo Zhao   +10 more
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Single‐cell RNA sequencing in cancer research

Journal of Experimental & Clinical Cancer Research, 2021
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell ...
Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Yixin Tan, Wei Xiong   +18 more
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Recent advances in deciphering hippocampus complexity using single-cell transcriptomics

Neurobiology of Disease, 2023
Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
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Application of single-cell RNA sequencing technologies in aortic dilatation diseases [PDF]

Jichu yixue yu linchuang, 2022
Aortic dilation disease, represented by aortic dissection and aortic aneurysm, is the most dangerous disease in vascular surgery. The pathogenesis of this disease is not very clear.
ZHENG Kai, REN Hua-liang, ZHANG Wang-de, LI Chun-min
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Overview of single‐cell RNA sequencing analysis and its application to spermatogenesis research

Reproductive Medicine and Biology, 2023
Background Single‐cell transcriptomics allows parallel analysis of multiple cell types in tissues. Because testes comprise somatic cells and germ cells at various stages of spermatogenesis, single‐cell RNA sequencing is a powerful tool for investigating ...
Takahiro Suzuki
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Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets

Genome Biology, 2023
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human tissue is important for understanding disease pathologies. However, several experimental and computational challenges impede transcriptomics-based deconvolution ...
Sean K. Maden, Sang Ho Kwon, Louise A. Huuki-Myers, Leonardo Collado-Torres, Stephanie C. Hicks, Kristen R. Maynard   +5 more
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Single-cell RNA-sequencing in asthma research

Frontiers in Immunology, 2022
Asthma is a complex and heterogeneous disease with multicellular involvement, and knowledge gaps remain in our understanding of the pathogenesis of asthma. Efforts are still being made to investigate the immune pathogenesis of asthma in order to identify
Weifeng Tang, Weifeng Tang, Mihui Li, Mihui Li, Fangzhou Teng, Fangzhou Teng, Jie Cui, Jie Cui, Jingcheng Dong, Jingcheng Dong, Wenqian Wang, Wenqian Wang   +11 more
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Single-Cell RNA Sequencing in Parkinson’s Disease

Biomedicines, 2021
Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) technologies have enhanced the understanding of the molecular pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD).
Shi-Xun Ma, Su Bin Lim
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scDA: Single cell discriminant analysis for single-cell RNA sequencing data

Computational and Structural Biotechnology Journal, 2021
Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi, Xinxing Li, Qirui Peng, Chuanchao Zhang, Luonan Chen   +4 more
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